Search Result
Gene Summary for CCKBR Gene
| Official Symbol |
CCKBR |
Gene Type |
protein-coding |
| Full Name |
cholecystokinin B receptor |
Entrez |
887
|
| Ensembl ID |
ENSG00000110148 |
HGNC |
1571
|
| Aliases |
CCK-B, CCK2R, GASR
|
Chromosome Location |
Chromosome 11, NC_000011.10 (6259838..6272127)
|
| Expression |
Biased expression in stomach (RPKM 4.6), brain (RPKM 2.9) and 2 other tissues
|
| Summary |
This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. Alternative splicing results in multiple transcript variants. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Dec 2015]
|
Paper for CCKBR Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27518872 |
Beiqin Yu |
2016 |
CCK-BR |
miR-148a-mediated anti-cancer effects are dependent on the inhibition of STAT3 and Akt activation, which subsequently regulates the pathways involved in cell proliferation and migration. |
Experiment for CCKBR Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
Cholecystokinin B receptor (CCK-BR) was a direct target of miR-148a. |
27518872 |
| cell line |
- |
- |
Cell proliferation assay; Cell migration assay |
- |
No Reports |
- |
- |
siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. |
siRNA-induced knockdown of CCK-BR elicited similar anti-oncogenic effects (decreased proliferation and migration) as those induced by enforced miR-148a expression. |
27518872 |
Function for CCKBR Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CCKBR Gene
| Interaction Gene |
Method |
PMID |
|
|
Luciferase reporter assay |
27518872
|
|
