Search Result
Gene Summary for CCN1 Gene
| Official Symbol |
CCN1 |
Gene Type |
protein-coding |
| Full Name |
cellular communication network factor 1 |
Entrez |
3491
|
| Ensembl ID |
ENSG00000142871 |
HGNC |
2654
|
| Aliases |
CYR61, GIG1, IGFBP10
|
Chromosome Location |
Chromosome 1, NC_000001.11 (85580761..85583950)
|
| Expression |
Broad expression in gall bladder (RPKM 285.2), spleen (RPKM 216.9) and 20 other tissues
|
| Summary |
The secreted protein encoded by this gene is growth factor-inducible and promotes the adhesion of endothelial cells. The encoded protein interacts with several integrins and with heparan sulfate proteoglycan. This protein also plays a role in cell proliferation, differentiation, angiogenesis, apoptosis, and extracellular matrix formation. [provided by RefSeq, Sep 2011]
|
Paper for CCN1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30178386 |
Jing Yan |
2019 |
CYR61 |
miR-142-5p-CYR61-Wnt/β-catenin axis partially illustrates the molecular mechanism of GC recurrence and represents a novel prognosis biomarker for GC. |
| 27105510 |
Jing Wei |
2016 |
CYR61 |
CYR61 as a metastatic biomarker for prediction of poor prognosis of GCA and provided a potential molecular target for anti-metastatic therapy of GCA |
Experiment for CCN1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
159 |
42 |
IHC |
China |
No Reports |
Up |
- |
- |
CYR61 protein in GC tissues was significantly higher than that in normal gastric tissues.CYR61 expression correlated with distant metastasis and recurrence. Positive CYR61 expression was significantly associated with poor overall survival. |
30178386 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CYR61 is a novel target of miR‑142‑5p in GC cells |
30178386 |
| tissue |
214 |
214 |
IHC |
China |
No Reports |
Up |
- |
- |
CYR61 is overexpressed in 44% of the GCA tumor samples. Expression of CYR61 is inversely correlated with cumulative survival of GCA patients (p<0. 001) and significantly associated only with metastatic pathological categories (with N category, p=0. 052; with TNM stage, p=0. 001). |
27105510 |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
knockdown of CYR61 in gastric cancer AGS cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis |
knockdown of CYR61 in gastric cancer AGS cells impairs the cancer cell migration and invasion, suggesting a driver role of CYR61 in metastasis |
27105510 |
Function for CCN1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.001 |
- |
Interaction for CCN1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-142-5p |
Luciferase reporter assay |
30178386
|
|
