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Gene Summary for CCND1 Gene

Official Symbol CCND1 Gene Type protein-coding
Full Name cyclin D1 Entrez 595
Ensembl ID ENSG00000110092 HGNC 1582
Aliases BCL1, D11S287E, PRAD1, U21B31 Chromosome Location Chromosome 11, NC_000011.10 (69641156..69654474)
Expression Ubiquitous expression in skin (RPKM 61.4), liver (RPKM 56.0) and 24 other tissues
Summary The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of human cancers. [provided by RefSeq, Dec 2019]

Paper for CCND1 Gene

PMID Author Year ID in Paper
 Conclusion
30810117 Datong Jiang 2019 Cyclin D1 lncRNA HOTAIR knockdown stimulates miR-454-3p expression to inhibit gastric cancer growth by depressing STAT3/Cyclin D1 activity.
29848678 Nan-Hua Chou 2018 CCND1 miR-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting CCND1 and ETS1 expression.
27071318 Lanlan Wang 2016 cyclin D1 Overexpression of miR-193b inhibited the expression of CCND1, and knock-down of CCND1 inhibited the proliferation of GC cells, suggesting that miR-193b exerted its anti-tumorigenic role in GC cells through targeting CCND1 gene.
26955820 Zhijun Ma 2016 cyclin D1 miR-155 may act as a potential diagnostic marker for early-stage GC and may represent a novel therapeutic target for GC treatment.
26791264 Chenwei Yuan 2016 cyclin D1 HOXA1 plays a crucial role in GC development and clinical prognosis. HOXA1, alone or combination with cyclin D1, may serve as a novel prognostic biomarker for GC.
23383271 Liduan Zheng 2013 cyclin D1 anti-miR-9 inhibitor promoted the proliferation, migration and invasion of gastric cancer cells, while knocking down of cyclin D1 or Ets1 partially phenocopied the effects of miR-9 over-expression.
14691913 Roger M Feakins 2003 cyclin D1 Rb pathway disturbances play an important role in gastric carcinogenesis. The poor prognosis of cancers with low pRb expression and the reduced pRb expression in lymph node metastases raise the possibility that Rb and related genes also influence progression.

Experiment for CCND1 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 30 30 IHC China No Reports Up - - Cyclin D1 protein expressions were significantly upregulated in cancer tissues.lncRNA HOTAIR was positively correlated with STAT3 and Cyclin D1 protein expressions in gastric cancer tissues. 30810117
cell line - - Cell proliferation assay; Cell colony formation assay; - No Reports - - Ectopic expressions of miR-193a-5p and miR-193a-3p revealed that they both inhibited gastric cancer cell growth, but only miR-193a-3p significantly suppressed cell invasion ability. ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression. 29848678
cell line - - Luciferase reporter assay - No Reports - - - ETS1 and CCND1 are direct targets of miR-193a-3p 29848678
cell line - - Cell proliferation assay; Invasion and migration assays - No Reports - - - Regulate cell growth of GC cells. 27071318
tissue 60 60 qRT-PCR China No Reports Up - - the cyclin D1 mRNA level was generally higher in GC samples when compared to their matched nontumor counterparts 26955820
cell line - - Cell proliferation assay; Flow cytometry - No Reports - - Enforced expression of miR-155 impaired GC cell proliferation, promoted G1 phase arrest and induced apoptosis in vitro. In addition, we identified cyclin D1 as the direct target of miR-155, and knockdown of cyclin D1 partially phenocopied the role of miR-155 in GC cells. The enforced expression of si-CCND1 notably repressed cells proliferation, elicited cell cycle arrest at the G0– G1 stage and enhanced apoptosis in both cell lines. 26955820
cell line - - Luciferase reporter assay - No Reports - - - Cyclin D1 is a direct target of miR-155 in GC cells 26955820
tissue 48 48 qRT-PCR China No Reports Up - - cyclin D1 mRNA expression were upregulated in GC tissues. A significant correlation was found between the expression of HOXA1 and cyclin D1. 26791264
tissue 264 264 IHC; Western blot China No Reports Up - - cyclin D1 protein expression were upregulated in GC tissue; Overexpression of cyclin D1 was significantly associated with differentiation; Cyclin D1 was also significantly associ- ated with DFS and OS. 26791264
tissue 86 86 qRT-PCR China No Reports Up - - cyclin D1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines. 23383271
cell line - - Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay - No Reports - - Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro. 23383271
cell line - - Luciferase reporter assay - No Reports - - - miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1 23383271
tissue 67 67 IHC U.K. No Reports Up - - Cyclin D1 overexpression (≥5% expression) was seen in 55% of cancers; Cyclin D1 overexpression was associated with poor differentiation and signet ring cell type. 14691913

Function for CCND1 Gene

Functional Type AUC Overall Survival Disease-free Survival
mechanism - - -
prognosis - < 0.001 < 0.001

Interaction for CCND1 Gene

Interaction Gene Method PMID
miR-193a-3p Luciferase reporter assay 29848678
miR-155 Luciferase reporter assay 26955820
miR-9 Luciferase reporter assay 23383271
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