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Gene Summary for CCND2 Gene
| Official Symbol |
CCND2 |
Gene Type |
protein-coding |
| Full Name |
cyclin D2 |
Entrez |
894
|
| Ensembl ID |
ENSG00000118971 |
HGNC |
1583
|
| Aliases |
KIAK0002, MPPH3
|
Chromosome Location |
Chromosome 12, NC_000012.12 (4273762..4305353)
|
| Expression |
Ubiquitous expression in adrenal (RPKM 22.1), heart (RPKM 18.6) and 24 other tissues
|
| Summary |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
|
Paper for CCND2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 14612939 |
Yasuhiro Oshimo |
2003 |
cyclin D2 |
DNA hypomethylation is a mechanism underlying the increased expression of cyclin D2 in cancer cells and that demethylation of cyclin D2 may be involved in development and progression of gastric carcinoma. |
Experiment for CCND2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
34 |
21 |
MS-PCR |
Japan |
No Reports |
Up(Methylation) |
Up(Methylation) |
- |
Hypomethylation of the cyclin D2 promoter was found in 24 (71%) of the 34 tumor tissues and in 6 (29%) of the 21 corresponding non-neoplastic mucosa, the incidence being significantly different (p=0.002; Fisher's exact test). Moreover, hypomethylation of cyclin D2 was more common in stage III and IV tumors than in stage I and II tumors. |
14612939 |
| tissue |
23 |
23 |
qRT-PCR |
China |
No Reports |
- |
- |
- |
Levels of cyclin D2 mRNA expression in tumor tissues with cyclin D2 hypomethylation (33.08±45.78) tended to be higher than those with cyclin D2 hypermethylation; levels of cyclin D2 mRNA expression in tumor tissues with metastasis (35.88+45.56) were significantly higher than those in tumors without metastasis. |
14612939 |
Function for CCND2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CCND2 Gene
| Interaction Gene |
Method |
PMID |
|
