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Gene Summary for CCR7 Gene
| Official Symbol |
CCR7 |
Gene Type |
protein-coding |
| Full Name |
C-C motif chemokine receptor 7 |
Entrez |
1236
|
| Ensembl ID |
ENSG00000126353 |
HGNC |
1608
|
| Aliases |
BLR2, CC-CKR-7, CCR-7, CD197, CDw197, CMKBR7, EBI1
|
Chromosome Location |
Chromosome 17, NC_000017.11 (40553769..40565472, complement)
|
| Expression |
Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues
|
| Summary |
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]
|
Paper for CCR7 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 23519840 |
Wei-ning Wang |
2013 |
CCR7 |
CCR7 protein plays a key role in the metastasis and progression of gastric cancer. The elevated CCR7 protein expression may be caused by the deficiency of let-7a miRNA expression due to the downregulation of DICER1gene expression. The mechanism for the silencing of DICER1 gene expression requires further studies. |
Experiment for CCR7 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
80 |
40 |
IHC |
China |
No Reports |
Up |
- |
- |
CCR7 protein plays a key role in the metastasis and progression of gastric cancer. The elevated CCR7 protein expression may be caused by the deficiency of let-7a miRNA expression due to the downregulation of DICER1gene expression. The mechanism for the silencing of DICER1 gene expression requires further studies. |
23519840 |
Function for CCR7 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for CCR7 Gene
| Interaction Gene |
Method |
PMID |
|
