Search Result
Gene Summary for CD14 Gene
| Official Symbol |
CD14 |
Gene Type |
protein-coding |
| Full Name |
CD14 molecule |
Entrez |
929
|
| Ensembl ID |
ENSG00000170458 |
HGNC |
1628
|
| Aliases |
|
Chromosome Location |
Chromosome 5, NC_000005.10 (140631732..140633701, complement)
|
| Expression |
Broad expression in placenta (RPKM 87.5), liver (RPKM 85.2) and 23 other tissues
|
| Summary |
The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide, and to viruses. This gene has been identified as a target candidate in the treatment of SARS-CoV-2-infected patients to potentially lessen or inhibit a severe inflammatory response. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Aug 2020]
|
Paper for CD14 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 17438094 |
Dan Zhao |
2007 |
CD14 |
Functional polymorphism in CD14 is associated with greater risk of H. pylori-related gastric carcinoma, which might be mediated by elevated sCD14. |
Experiment for CD14 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| blood |
470 |
470 |
Reporter gene assays; PCR-RFLP methods |
China |
Related |
- |
- |
- |
Two SNPs (-651C>T and -260C>T) were identified, of which the -260CT and -260TT genotypes were associated with elevated risk of gastric carcinoma (OR, 1.77; 95% CI, 1.09-2.85 and OR, 1.95; 95% CI, 1.20-3.16, respectively). Haplotype analysis suggested a synergistic effect of the two SNPs (OR for the T(-651)-T(-260) haplotype, 3.39 versus OR for the C(-651)-T(-260) haplotype, 1.45; P = 0.02), which is consistent with reporter gene assays. A multiplicative joint effect between H. pylori infection and -260C>T polymorphism was observed (OR for the presence of both -260TT genotype and H. pylori infection, 4.03; 95% CI, 1.80-9.04). Patients had significantly higher sCD14 than controls (1,866 +/- 2,535 ng/mL versus 1,343 +/- 2,119 ng/mL; P < 0.001), and this difference was associated with the CD14 -260 polymorphism and H. pylori infection. |
17438094 |
Function for CD14 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for CD14 Gene
| Interaction Gene |
Method |
PMID |
|
