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Gene Summary for CD151 Gene
| Official Symbol |
CD151 |
Gene Type |
protein-coding |
| Full Name |
CD151 molecule (Raph blood group) |
Entrez |
977
|
| Ensembl ID |
ENSG00000177697 |
HGNC |
1630
|
| Aliases |
GP27, MER2, PETA-3, RAPH, SFA1, TSPAN24
|
Chromosome Location |
Chromosome 11, NC_000011.10 (832952..838835)
|
| Expression |
Ubiquitous expression in fat (RPKM 188.8), lung (RPKM 142.9) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. It is involved in cellular processes including cell adhesion and may regulate integrin trafficking and/or function. This protein enhances cell motility, invasion and metastasis of cancer cells. Multiple alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
|
Paper for CD151 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 23533596 |
Yue-Ming Yang |
2013 |
CD151 |
CD151 is positively associated with the invasiveness of HGC, and CD151 or the combination of CD151 and integrin a3 is a novel marker for predicting the prognosis of HGC patients and may be potential therapeutic targets. |
Experiment for CD151 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
20 |
20 |
qRT-PCR; Western blot |
China |
No Reports |
Up |
- |
- |
CD151 mRNA and protein expression was increased in HGC tissues and HGC cells than in nontumor tissues and HGEC cells. CD151 overexpression was significantly correlated with high TNM stage, depth of invasion and positive lymph node involvement (p<0.05), and Importantly, the postoperative 5-year overall survival of patients with CD151(low) and/or integrin a3(low) was higher than that of patients with CD151(high) and/or integrin a3(high). |
23533596 |
| tissue |
76 |
- |
IHC |
China |
No Reports |
- |
- |
- |
CD151 protein immunoreactivity localized to the cell membrane. High expression of CD151 was significantly correlated with tumor size (p = 0.021), depth of invasion (p = 0.004), lymph node involvement (p =0.028) and high tumor stage (p = 0.002). Overexpression of CD151 are Independent Factors Predicting the Prognosis of HGC Patients. |
23533596 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
Down-regulation of CD151 by vshRNA-CD151 impaired metastasis and invasion of HGC-27 cells, but did not affect cell proliferation. |
Down-regulation of CD151 by vshRNA-CD151 impaired metastasis and invasion of HGC-27 cells, but did not affect cell proliferation. CD151-cDNA transfection rescued the metastatic potential and invasiveness of HGC-27-vshCD151 cells, but not those of HGC-27-vshintegrin a3 cells in vitro. |
23533596 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
CD151 Promoted Metastasis of HGC Cells in vivo |
23533596 |
| cell line |
- |
- |
Co-ip assays |
- |
No Reports |
- |
- |
- |
CD151 formed a complex with integrin a3 in HGC cells. |
23533596 |
Function for CD151 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
0.007 |
- |
Interaction for CD151 Gene
| Interaction Gene |
Method |
PMID |
|
