Search Result
Gene Summary for CD274 Gene
| Official Symbol |
CD274 |
Gene Type |
protein-coding |
| Full Name |
CD274 molecule |
Entrez |
29126
|
| Ensembl ID |
ENSG00000120217 |
HGNC |
17635
|
| Aliases |
B7-H, B7H1, PD-L1, PDCD1L1, PDCD1LG1, PDL1, hPD-L1
|
Chromosome Location |
Chromosome 9, NC_000009.12 (5450542..5470554)
|
| Expression |
Broad expression in appendix (RPKM 6.7), placenta (RPKM 4.5) and 23 other tissues
|
| Summary |
This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
|
Paper for CD274 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29073638 |
An Na Seo |
2017 |
PD-L1 |
Intraepithelial tumour cells PD-L1 expression can be used to predict a poor outcome in patients with EBVaGC and can represent a rational approach for PD-1/PD-L pathway-targeted immunotherapy. |
Experiment for CD274 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
116 |
- |
IHC |
Korea |
No Reports |
- |
- |
- |
Among 116 eligible patients, 57 (49.1%) and 66 patients (56.9%) were determined as iTu-PD-L1-positive and str-PD-L1-positive. Intraepithelial tumour cell PD-L1 positivity was found to be significantly associated with lymph node (LN) metastasis and a poor disease-free survival (DFS) (P=0.032), yet not overall survival (P=0.482). In a multivariate analysis, iTu-PD-L1 positivity was independently associated with a poor DFS (P=0.006, hazard ratio=12.085). |
29073638 |
Function for CD274 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.482 |
0.032 |
Interaction for CD274 Gene
| Interaction Gene |
Method |
PMID |
|
