Search Result
Gene Summary for CD276 Gene
| Official Symbol |
CD276 |
Gene Type |
protein-coding |
| Full Name |
CD276 molecule |
Entrez |
80381
|
| Ensembl ID |
ENSG00000103855 |
HGNC |
19137
|
| Aliases |
4Ig-B7-H3, B7-H3, B7H3, B7RP-2
|
Chromosome Location |
Chromosome 15, NC_000015.10 (73683966..73714518)
|
| Expression |
Ubiquitous expression in placenta (RPKM 22.3), gall bladder (RPKM 17.0) and 24 other tissues
|
| Summary |
The protein encoded by this gene belongs to the immunoglobulin superfamily, and thought to participate in the regulation of T-cell-mediated immune response. Studies show that while the transcript of this gene is ubiquitously expressed in normal tissues and solid tumors, the protein is preferentially expressed only in tumor tissues. Additionally, it was observed that the 3' UTR of this transcript contains a target site for miR29 microRNA, and there is an inverse correlation between the expression of this protein and miR29 levels, suggesting regulation of expression of this gene product by miR29. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
|
Paper for CD276 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25120098 |
Wei Dai |
2014 |
B7-H3 |
B7-H3 is aberrantly expressed in gastric cancer. In addition to modulating tumor immunity, B7-H3 may have a novel role in regulating SGC-7901 cell metastasis. |
Experiment for CD276 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
32 |
32 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. |
25120098 |
| tissue |
32 |
32 |
IHC |
China |
No Reports |
Up |
- |
- |
B7-H3 expression was significantly higher in the gastric cancer group than that in the normal gaster group. |
25120098 |
| cell line |
- |
- |
Cell invasion and migration assays |
- |
No Reports |
- |
- |
B7-H3 expression reduced gastric cancer metastasis in vivo。 |
B7-H3 knockdown by RNA interference decreased cell migration and Transwell invasion up to 50% in vitro. |
25120098 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
B7-H3 expression reduced gastric cancer metastasis in vivo。 |
25120098 |
Function for CD276 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CD276 Gene
| Interaction Gene |
Method |
PMID |
|
