Gastric Cancer Database

Official Symbol	CDC42	Gene Type	protein-coding
Full Name	cell division cycle 42	Entrez	998
Ensembl ID	ENSG00000070831	HGNC	1736
Aliases	CDC42Hs, G25K, TKS	Chromosome Location	Chromosome 1, NC_000001.11 (22052709..22101360)
Expression	Ubiquitous expression in bone marrow (RPKM 88.8), colon (RPKM 72.7) and 25 other tissues
Summary	The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. [provided by RefSeq, Apr 2013]

PMID	Author	Year	ID in Paper	Conclusion
26549550	Dong-Shu Du	2016	CDC42	CDC42 is a key regulator involved in regulating the proliferation, migration and invasion of GC, and it may be considered a potential therapeutic target in GC.
25152372	Zhenguo Cheng	2014	CDC42	Our findings could provide new insights into the molecular mechanisms of gastric carcinogenesis, and may help facilitating development of CDC42/PAK-based therapies for human cancer.

Sample Type	Sample Number GC	Sample Number nonGC	Method	Region	Hpylori	Normal vs. GC	Early-stage vs. Advanced stage	Biological Functions in GC Cells	Result	PMID
cell line	-	-	Cell proliferation assay; Invasion and migration assays	-	No Reports	-	-	Knockdown of CDC42 significantly inhibited the proliferation of AGS and SGC7901 cells, and it was suggested that this inhibitory process may be due to cell cycle arrest at G1/S phase and downregulation of cyclin A, cyclin D1, cyclin E and proliferating cell nuclear antigen. Furthermore, knockdown of CDC42 markedly inhibited the migration and invasion of GC cells, and suppressed the expression of matrix metalloproteinase 9	Knockdown of CDC42 significantly inhibited the proliferation of AGS and SGC7901 cells, and it was suggested that this inhibitory process may be due to cell cycle arrest at G1/S phase and downregulation of cyclin A, cyclin D1, cyclin E and proliferating cell nuclear antigen. Furthermore, knockdown of CDC42 markedly inhibited the migration and invasion of GC cells, and suppressed the expression of matrix metalloproteinase 9	26549550
tissue	18	18	Western blot	China	No Reports	Up	-	-	The protein expression of CDC42 was significantly up-regulated in cancer tissues.	25152372
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	CDC42 is the direct target of miR-133a	25152372

Interaction Gene	Method	PMID
CDC42	Luciferase reporter assay	25152372