Search Result
Gene Summary for CDH1 Gene
| Official Symbol |
CDH1 |
Gene Type |
protein-coding |
| Full Name |
cadherin 1 |
Entrez |
999
|
| Ensembl ID |
ENSG00000039068 |
HGNC |
1748
|
| Aliases |
Arc-1, BCDS1, CD324, CDHE, ECAD, LCAM, UVO
|
Chromosome Location |
Chromosome 16, NC_000016.10 (68737292..68835537)
|
| Expression |
Broad expression in thyroid (RPKM 81.8), colon (RPKM 70.0) and 17 other tissues
|
| Summary |
This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]
|
Paper for CDH1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30063010 |
Wei Li |
2018 |
CDH1 |
we constructed the negative correlation between miR-217 and CDH1 level in GC patients and cells |
| 24023308 |
Kyung Hwa Lee |
2013 |
CDH1 |
The current study showed that the majority of DGC cases demonstrated concurrent CDH1 promoter methylation in tumor tissues and in non-neoplastic mucosa. |
Experiment for CDH1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
67 |
67 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
The mRNA level of CDH1 was found reduced in the GC tissues and there is a negative correlation between the expression of CDH1 and miR-217 in the GC samples. |
30063010 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CDH1 is a direct target of miR-217 |
30063010 |
| tissue |
72 |
72 |
MS-PCR |
Korea |
No Reports |
- |
- |
- |
MSP and PS revealed CDH1 promoter methylation in 73.6% (53/72) and 77.8% (56/72) of DGC samples, respectively. PS detected CDH1 methylation in 70.8% (51/72) and 72.2% (52/72) of matched normal mucosa from adjacent and remote foci, respectively. In comparison, CDH1 promoter methylation was detected in 12/24 normal gastric mucosa samples without DGC, and this difference was statistically significant (p=0.016). |
24023308 |
Function for CDH1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CDH1 Gene
| Interaction Gene |
Method |
PMID |
|
CDH1 |
Luciferase reporter assay |
30063010
|
|
