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Gene Summary for CDK6 Gene
| Official Symbol |
CDK6 |
Gene Type |
protein-coding |
| Full Name |
cyclin dependent kinase 6 |
Entrez |
1021
|
| Ensembl ID |
ENSG00000105810 |
HGNC |
1777
|
| Aliases |
MCPH12, PLSTIRE
|
Chromosome Location |
Chromosome 7, NC_000007.14 (92604921..92836573, complement)
|
| Expression |
Ubiquitous expression in placenta (RPKM 9.3), bone marrow (RPKM 7.6) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. This kinase is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression and G1/S transition. The activity of this kinase first appears in mid-G1 phase, which is controlled by the regulatory subunits including D-type cyclins and members of INK4 family of CDK inhibitors. This kinase, as well as CDK4, has been shown to phosphorylate, and thus regulate the activity of, tumor suppressor protein Rb. Altered expression of this gene has been observed in multiple human cancers. A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. [provided by RefSeq, Aug 2017]
|
Paper for CDK6 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30530570 |
Yan Jia |
2019 |
CDK6 |
A tumor-suppressive role of miR-1296-5p through the translational repression of oncogenic CDK6 and EGFR in gastric cancer. |
Experiment for CDK6 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
40 |
40 |
IHC |
China |
No Reports |
- |
- |
- |
EGFR and CDK6 are up-regulated in GC and negatively correlated with miR-1296-5p |
30530570 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
EGFR and CDK6 are directly targets of miR-1296-5p |
30530570 |
Function for CDK6 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for CDK6 Gene
| Interaction Gene |
Method |
PMID |
|
miR-1296-5p |
Luciferase reporter assay |
30530570
|
|
