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Gene Summary for CDK9 Gene
| Official Symbol |
CDK9 |
Gene Type |
protein-coding |
| Full Name |
cyclin dependent kinase 9 |
Entrez |
1025
|
| Ensembl ID |
ENSG00000136807 |
HGNC |
1780
|
| Aliases |
C-2k, CDC2L4, CTK1, PITALRE, TAK
|
Chromosome Location |
Chromosome 9, NC_000009.12 (127786034..127790792)
|
| Expression |
Ubiquitous expression in ovary (RPKM 32.0), spleen (RPKM 23.0) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of S. cerevisiae cdc28, and S. pombe cdc2, and known as important cell cycle regulators. This kinase was found to be a component of the multiprotein complex TAK/P-TEFb, which is an elongation factor for RNA polymerase II-directed transcription and functions by phosphorylating the C-terminal domain of the largest subunit of RNA polymerase II. This protein forms a complex with and is regulated by its regulatory subunit cyclin T or cyclin K. HIV-1 Tat protein was found to interact with this protein and cyclin T, which suggested a possible involvement of this protein in AIDS. [provided by RefSeq, Jul 2008]
|
Paper for CDK9 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28701053 |
Yebin Lu |
2018 |
CDK9 |
miR-613, as a tumour suppressor, involves in gastric cancer progression and metastasis by targeting CDK9, implying a novel potential therapeutic target for the treatment of gastric cancer. |
Experiment for CDK9 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
52 |
52 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
CDK9 was upregulated in gastric cancer and the CDK9 expression levels were inversely correlated with that of miR-613 in gastric cancer tissues. |
28701053 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CDK9 is a direct target of miR-613 in gastric cancer |
28701053 |
Function for CDK9 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CDK9 Gene
| Interaction Gene |
Method |
PMID |
|
miR-613 |
Luciferase reporter assay |
28701053
|
|
