Search Result
Gene Summary for CDKL1 Gene
| Official Symbol |
CDKL1 |
Gene Type |
protein-coding |
| Full Name |
cyclin dependent kinase like 1 |
Entrez |
8814
|
| Ensembl ID |
ENSG00000100490 |
HGNC |
1781
|
| Aliases |
KKIALRE, P42
|
Chromosome Location |
Chromosome 14, NC_000014.9 (50326265..50397399, complement)
|
| Expression |
Ubiquitous expression in kidney (RPKM 3.9), endometrium (RPKM 2.6) and 24 other tissues
|
| Summary |
This gene product is a member of a large family of CDC2-related serine/threonine protein kinases that accumulates primarily in the nucleus. [provided by RefSeq, Nov 2018]
|
Paper for CDKL1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 22369697 |
Wei Sun |
2012 |
Cdkl1 |
CDKL1 plays an important regulatory role in gastric cancer cell proliferation and survival, and therefore, may represent a new target for therapeutic intervention. |
Experiment for CDKL1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
66 |
66 |
IHC |
China |
No Reports |
Up |
- |
- |
High expression of CDKL1 protein was observed in gastric cancer tissues compared with matched adjacent tissues. Furthermore, we show that the reduction of CDKL1 with its siRNA stimulates the activation of Bcl-2-interacting killer (Bik) pro-apoptotic protein and attenuated the expression of proliferating cell nuclear antigen PCNA. |
22369697 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; Cell colony forming assay; |
- |
No Reports |
- |
- |
Loss of CDKL1 function in both SGC7901 and MGC-803 gastric cancer cells significantly decreases cellular proliferation and increases apoptosis (p < 0.01). |
Loss of CDKL1 function in both SGC7901 and MGC-803 gastric cancer cells significantly decreases cellular proliferation and increases apoptosis (p < 0.01). |
22369697 |
Function for CDKL1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CDKL1 Gene
| Interaction Gene |
Method |
PMID |
|
