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Gene Summary for CDKN1A Gene
| Official Symbol |
CDKN1A |
Gene Type |
protein-coding |
| Full Name |
cyclin dependent kinase inhibitor 1A |
Entrez |
1026
|
| Ensembl ID |
ENSG00000124762 |
HGNC |
1784
|
| Aliases |
CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
|
Chromosome Location |
Chromosome 6, NC_000006.12 (36676463..36687332)
|
| Expression |
Ubiquitous expression in colon (RPKM 71.4), gall bladder (RPKM 68.8) and 24 other tissues
|
| Summary |
This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-cyclin-dependent kinase2 or -cyclin-dependent kinase4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen, a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of cyclin-dependent kinase2, and may be instrumental in the execution of apoptosis following caspase activation. Mice that lack this gene have the ability to regenerate damaged or missing tissue. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Sep 2015]
|
Paper for CDKN1A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29434197 |
Xingchen Dong |
2018 |
p21 |
Our results reveal a novel mechanism by which BRD4 regulates cancer cell proliferation by modulating the cellular senescence through E2F/miR-106b-5p/p21 axis and provide new insights into using BET inhibitors as potential anticancer drugs. |
| 25959498 |
Yongchao Liu |
2015 |
p21 |
These results delineate a novel mechanism of lncRNA GAS5 in suppressing stomach carcinogenesis, and the lncRNA GAS5/YBX1/p21 pathway we discovered may provide useful targets for developing lncRNA-based therapies for stomach cancer. |
Experiment for CDKN1A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
BRD4 regulates the 3′-UTR of p21. mRNA CDKN1A |
29434197 |
| tissue |
55 |
55 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
p21 mRNA level was significantly down-regulated in 72.7% of cancer tissues compared with paired normal tissues, which was positively correlated with decreased lncRNA GAS5 expression in tissue specimens |
25959498 |
Function for CDKN1A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for CDKN1A Gene
| Interaction Gene |
Method |
PMID |
|
BRD4 |
Luciferase reporter assay |
29434197
|
|
