Search Result
Gene Summary for CDKN2B-AS1 Gene
| Official Symbol |
CDKN2B-AS1 |
Gene Type |
lncRNA |
| Full Name |
CDKN2B antisense RNA 1 |
Entrez |
100048912
|
| Ensembl ID |
ENSG00000240498 |
HGNC |
34341
|
| Aliases |
ANRIL; p15AS; PCAT12; CDKN2BAS; CDKN2B-AS; NCRNA00089
|
Chromosome Location |
Chromosome 9, NC_000009.12 (21994791..22121097)
|
| Expression |
Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.7) and 1 other tissue
|
| Summary |
This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
|
Paper for CDKN2B-AS1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31242038 |
Wei Deng |
2019 |
LncRNA-ANRIL |
ANRIL would be a potential biomarker and therapeutic target for gastric cancer prognosis and treatment. |
| 30156609 |
Pei Liu |
2018 |
ANRIL |
Provided a novel regulatory mechanism for ANRIL in gastric cancer, in which ANRIL silence down-regulated BMI1 via miR-99a, along with activation of the apoptotic pathway and inhibition of the Notch and mTOR pathways |
Experiment for CDKN2B-AS1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
192 |
- |
PCR |
China |
No Reports |
- |
- |
- |
Patients with higher ANRIL survived worse. Expressions of TET2 and ANRIL were negatively correlated in the patient samples. |
31242038 |
| cell line |
- |
- |
Apoptosis assay; Migration assay |
- |
No Reports |
- |
- |
ANRIL suppresses apoptosis in gastric cancer cell |
ANRIL suppresses apoptosis in gastric cancer cell, enhances metastasis |
31242038 |
| cell line |
- |
- |
Xenograft tumor mouse model |
- |
No Reports |
- |
- |
ANRIL promotes tumor growth in vivo |
ANRIL promotes tumor growth in vivo |
31242038 |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
ANRIL level was elevated in gastric cancer tissues and cell lines. Furthermore, ANRIL silence down-regulated BMI1 via up-regulating miR-99a. BMI1 silence down-regulated Bcl-2 and key kinases in the Notch and mTOR pathways and up-regulated p16 and cleaved caspases. |
30156609 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
Knockdown of ANRIL suppressed cell viability, migration, and invasion, and increased apoptosis through up-regulating miR-99a. |
Knockdown of ANRIL suppressed cell viability, migration, and invasion, and increased apoptosis through up-regulating miR-99a. |
30156609 |
| cell line |
- |
- |
qRT-PCR; Cell transfection |
- |
No Reports |
- |
- |
- |
ANRIL silence_x005finduced up-regulation of miR-99a was significantly reversed by miR-99a inhibitor.ANRIL knockdown down-regulated the expression of BMI1 by modulating miR-99a in gastric cancer cells in vitro |
30156609 |
Function for CDKN2B-AS1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
< 0.001 |
- |
| target |
- |
- |
- |
Interaction for CDKN2B-AS1 Gene
| Interaction Gene |
Method |
PMID |
Gene Summary for CDKN2B-AS1 Gene
| Official Symbol |
CDKN2B-AS1 |
Gene Type |
lncRNA |
| Full Name |
CDKN2B antisense RNA 1 |
Entrez |
100048912
|
| Ensembl ID |
ENSG00000240498 |
HGNC |
34341
|
| Aliases |
ANRIL, CDKN2B-AS, CDKN2BAS, NCRNA00089, PCAT12, p15AS
|
Chromosome Location |
Chromosome 9, NC_000009.12 (21994791..22121097)
|
| Expression |
Biased expression in small intestine (RPKM 5.1), colon (RPKM 4.7) and 1 other tissue
|
| Summary |
This gene is located within the CDKN2B-CDKN2A gene cluster at chromosome 9p21. The gene product is a functional RNA molecule that interacts with polycomb repressive complex-1 (PRC1) and -2 (PRC2), leading to epigenetic silencing of other genes in this cluster. This region is a significant genetic susceptibility locus for cardiovascular disease, and has also been linked to a number of other pathologies, including several cancers, intracranial aneurysm, type-2 diabetes, periodontitis, Alzheimer's disease, endometriosis, frailty in the elderly, and glaucoma. Multiple alternatively processed transcript variants have been detected, some of which may take the form of circular RNA molecules (PMID:21151960). [provided by RefSeq, May 2014]
|
Paper for CDKN2B-AS1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31242038 |
Wei Deng |
2019 |
LncRNA-ANRIL |
ANRIL would be a potential biomarker and therapeutic target for gastric cancer prognosis and treatment. |
| 30156609 |
Pei Liu |
2018 |
ANRIL |
Provided a novel regulatory mechanism for ANRIL in gastric cancer, in which ANRIL silence down-regulated BMI1 via miR-99a, along with activation of the apoptotic pathway and inhibition of the Notch and mTOR pathways |
Experiment for CDKN2B-AS1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
192 |
- |
PCR |
China |
No Reports |
- |
- |
- |
Patients with higher ANRIL survived worse. Expressions of TET2 and ANRIL were negatively correlated in the patient samples. |
31242038 |
| cell line |
- |
- |
Apoptosis assay; Migration assay |
- |
No Reports |
- |
- |
ANRIL suppresses apoptosis in gastric cancer cell |
ANRIL suppresses apoptosis in gastric cancer cell, enhances metastasis |
31242038 |
| cell line |
- |
- |
Xenograft tumor mouse model |
- |
No Reports |
- |
- |
ANRIL promotes tumor growth in vivo |
ANRIL promotes tumor growth in vivo |
31242038 |
| tissue |
20 |
20 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
ANRIL level was elevated in gastric cancer tissues and cell lines. Furthermore, ANRIL silence down-regulated BMI1 via up-regulating miR-99a. BMI1 silence down-regulated Bcl-2 and key kinases in the Notch and mTOR pathways and up-regulated p16 and cleaved caspases. |
30156609 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
Knockdown of ANRIL suppressed cell viability, migration, and invasion, and increased apoptosis through up-regulating miR-99a. |
Knockdown of ANRIL suppressed cell viability, migration, and invasion, and increased apoptosis through up-regulating miR-99a. |
30156609 |
| cell line |
- |
- |
qRT-PCR; Cell transfection |
- |
No Reports |
- |
- |
- |
ANRIL silence_x005finduced up-regulation of miR-99a was significantly reversed by miR-99a inhibitor.ANRIL knockdown down-regulated the expression of BMI1 by modulating miR-99a in gastric cancer cells in vitro |
30156609 |
Function for CDKN2B-AS1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
< 0.001 |
- |
| target |
- |
- |
- |
Interaction for CDKN2B-AS1 Gene
| Interaction Gene |
Method |
PMID |
|
