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Gene Summary for CEBPA Gene
| Official Symbol |
CEBPA |
Gene Type |
protein-coding |
| Full Name |
CCAAT enhancer binding protein alpha |
Entrez |
1050
|
| Ensembl ID |
ENSG00000245848 |
HGNC |
1833
|
| Aliases |
C/EBP-alpha, CEBP
|
Chromosome Location |
Chromosome 19, NC_000019.10 (33299934..33302564, complement)
|
| Expression |
-
|
| Summary |
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
|
Paper for CEBPA Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 20386538 |
Regalo |
2010 |
CEBPA |
C/EBP alpha (together with other members of the C/EBP family) has an active role in the control of differentiation and proliferation in normal gastric mucosa. In GC, loss of C/EBP alpha may be associated with the switch from a cellular differentiation to a cellular proliferation program, presumably as a consequence of Ras/MAPK pathway activation. |
Experiment for CEBPA Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
54 |
- |
IHC |
Portugal |
No Reports |
- |
- |
- |
In GC, C/EBPa staining was mostly nuclear with some residual cytoplasmic positivity. In GC, C/ EBPa was considered downregulated in 30% of the tumors. No statistical significant relationships were found between C/EBPa expression and any clin- icopathological features of the cases. |
20386538 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
- |
We observed a significant decrease in proliferation in C/EBPa-transfected cells. |
20386538 |
Function for CEBPA Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CEBPA Gene
| Interaction Gene |
Method |
PMID |
|
