Search Result
Gene Summary for CELF2 Gene
| Official Symbol |
CELF2 |
Gene Type |
protein-coding |
| Full Name |
CUGBP Elav-like family member 2 |
Entrez |
10659
|
| Ensembl ID |
ENSG00000048740 |
HGNC |
2550
|
| Aliases |
BRUNOL3, CELF-2, CUG-BP2, CUGBP2, ETR-3, ETR3, NAPOR
|
Chromosome Location |
Chromosome 10, NC_000010.11 (10462515..11336675)
|
| Expression |
Broad expression in brain (RPKM 19.5), bone marrow (RPKM 16.3) and 21 other tissues
|
| Summary |
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
|
Paper for CELF2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29501762 |
Jizhao Wang |
2018 |
CELF2 |
miR-615-3p promotes gastric cancer proliferation and migration by suppressing CELF2 expression for the first time, providing clues for future clinical practices |
Experiment for CELF2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
104 |
104 |
IHC |
China |
No Reports |
Down |
- |
- |
CELF2 was predominately down regulated in 86 gastric cancer tissues and highly ex- pressed in 18 cancer tissues compared with para-cancer tissues (69 high expressed and 35 low expressed). CELF2 expression was associated with T, N and M stage. Lower expression of CELF2 correlated to shorter period of survival months. |
29501762 |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry; Cell migration assay |
- |
No Reports |
- |
- |
Overexpressed CELF2 induced cell apoptosis and reduced proliferation ability. |
Overexpressed CELF2 induced cell apoptosis and reduced proliferation ability. |
29501762 |
Function for CELF2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.01 |
- |
Interaction for CELF2 Gene
| Interaction Gene |
Method |
PMID |
|
