Search Result
Gene Summary for CEMIP Gene
| Official Symbol |
CEMIP |
Gene Type |
protein-coding |
| Full Name |
cell migration inducing hyaluronidase 1 |
Entrez |
57214
|
| Ensembl ID |
ENSG00000103888 |
HGNC |
29213
|
| Aliases |
CCSP1, HYBID, KIAA1199, TMEM2L
|
Chromosome Location |
Chromosome 15, NC_000015.10 (80779370..80951771)
|
| Expression |
Biased expression in endometrium (RPKM 32.4), appendix (RPKM 6.2) and 5 other tissues
|
| Summary |
-
|
Paper for CEMIP Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28422983 |
Shuqin Jia |
2017 |
KIAA1199 |
These findings demonstrated that KIAA1199 was upregulated in GC tissue and associated with worse clinical outcomes in GC, and KIAA1199 acted as an oncogene by promoting migration and invasion through the enhancement of Wnt/β-catenin signaling pathway and MMPs mediated EMT progression in GC cells. |
Experiment for CEMIP Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
321 |
- |
qRT-PCR |
China |
No Reports |
- |
- |
- |
KIAA1199 was upregulated in GC tissue and was an essential independent marker for poor prognosis. KIAA1199 mRNA expression was correlated with the clinical characteristics regarding depth of invasion (T-staging), distant metastasis (M-staging) and TNM staging of GC patients. |
28422983 |
| tissue |
123 |
- |
IHC |
China |
No Reports |
- |
- |
- |
KIAA1199 protein expression was highly expressed in the cytoplasm of GC tissue cells and was correlated with depth of invasion, lymph node status (N-staging), metastasis and TNM staging |
28422983 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay |
- |
No Reports |
- |
- |
Knockdown KIAA1199 suppressed the proliferation, migration and invasion in GC cells. KIAA1199 stimulated the Wnt/β-catenin signaling pathway and the enzymatic activity of matrix metalloproteinase (MMP) family members and thus accelerated the epithelial-to-mesenchymal transition (EMT) progression in GC cells. |
Knockdown KIAA1199 suppressed the proliferation, migration and invasion in GC cells. KIAA1199 stimulated the Wnt/β-catenin signaling pathway and the enzymatic activity of matrix metalloproteinase (MMP) family members and thus accelerated the epithelial-to-mesenchymal transition (EMT) progression in GC cells. |
28422983 |
Function for CEMIP Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
< 0.001 |
- |
Interaction for CEMIP Gene
| Interaction Gene |
Method |
PMID |
|
