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Gene Summary for CHD1L Gene
| Official Symbol |
CHD1L |
Gene Type |
protein-coding |
| Full Name |
chromodomain helicase DNA binding protein 1 like |
Entrez |
9557
|
| Ensembl ID |
ENSG00000131778 |
HGNC |
1916
|
| Aliases |
ALC1, CHDL
|
Chromosome Location |
Chromosome 1, NC_000001.11 (147172747..147295762)
|
| Expression |
Ubiquitous expression in testis (RPKM 13.4), bone marrow (RPKM 10.4) and 25 other tissues
|
| Summary |
This gene encodes a DNA helicase protein involved in DNA repair. The protein converts ATP to add poly(ADP-ribose) as it regulates chromatin relaxation following DNA damage. Overexpression of this gene has been linked to several types of cancers. [provided by RefSeq, Feb 2017]
|
Paper for CHD1L Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24258459 |
Z Su |
2014 |
CHD1L |
These results indicated that CHD1L could serve as a prognostic marker for GC. |
Experiment for CHD1L Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
34 |
34 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
The gene expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. |
24258459 |
| tissue |
34 |
34 |
Western blot |
China |
No Reports |
Up |
- |
- |
The protein expression levels of CHD1L were higher in fresh samples of GC than in paired adjacent noncancerous tissues. |
24258459 |
| tissue |
616 |
616 |
IHC |
China |
No Reports |
Up |
- |
- |
Positive expression rates of CHD1L in GC and paired adjacent noncancerous tissues were 58.7 % (361/616) and 7.3 % (45/616), respectively. CHD1L positivity was significantly associated with clinical stage and distant metastasis. GC patients with positive CHD1L expression had shorter overall survival than those with negative CHD1L expression. Multivariate analysis showed that CHD1L was an independent prognostic marker for overall survival [Hazard Ratio (HR) = 5.952, 95 % confidence interval (CI) = 3.194-11.187, P = 0.0043]. |
24258459 |
Function for CHD1L Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.001 |
- |
Interaction for CHD1L Gene
| Interaction Gene |
Method |
PMID |
|
