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Gene Summary for CHD5 Gene
| Official Symbol |
CHD5 |
Gene Type |
protein-coding |
| Full Name |
chromodomain helicase DNA binding protein 5 |
Entrez |
26038
|
| Ensembl ID |
ENSG00000116254 |
HGNC |
16816
|
| Aliases |
CHD-5
|
Chromosome Location |
Chromosome 1, NC_000001.11 (6101787..6180321, complement)
|
| Expression |
Biased expression in brain (RPKM 14.5), testis (RPKM 9.9) and 1 other tissue
|
| Summary |
This gene encodes a member of the chromodomain helicase DNA-binding protein family. Members of this family are characterized by a chromodomain, a helicase ATP-binding domain and an additional functional domain. This gene encodes a neuron-specific protein that may function in chromatin remodeling and gene transcription. This gene is a potential tumor suppressor gene that may play a role in the development of neuroblastoma. [provided by RefSeq, Feb 2012]
|
Paper for CHD5 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 19840376 |
Xian Wang |
2009 |
CHD5 |
CHD5 was a TSG epigenetically down-regulated in gastric cancer. |
Experiment for CHD5 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
qRT-PCR |
- |
No Reports |
- |
- |
- |
CHD5 expression was down-regulated in all of gastric cancer cell lines used (100%, 7/7). |
19840376 |
| tissue/cell line |
- |
- |
MS-PCR; BGS |
- |
No Reports |
- |
- |
- |
Methylation of CHD5 promoter was detected in all of seven gastric cancer cell lines and in the majority of primary gastric carcinoma tissues examined (73%, 11/15). |
19840376 |
| cell line |
- |
- |
Colony formation assay |
- |
No Reports |
- |
- |
ectopic expression of CHD5 in gastric cancer cells led to a significant growth inhibition. |
ectopic expression of CHD5 in gastric cancer cells led to a significant growth inhibition. |
19840376 |
Function for CHD5 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CHD5 Gene
| Interaction Gene |
Method |
PMID |
|
