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Gene Summary for CHFR Gene
| Official Symbol |
CHFR |
Gene Type |
protein-coding |
| Full Name |
checkpoint with forkhead and ring finger domains |
Entrez |
55743
|
| Ensembl ID |
ENSG00000072609 |
HGNC |
20455
|
| Aliases |
RNF116, RNF196
|
Chromosome Location |
Chromosome 12, NC_000012.12 (132832356..132887618, complement)
|
| Expression |
Ubiquitous expression in testis (RPKM 9.9), spleen (RPKM 8.8) and 25 other tissues
|
| Summary |
This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]
|
Paper for CHFR Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 20300977 |
Shi-Lian Hu |
2011 |
CHFR |
Aberrant promoter methylation of Runx3 and CHFR genes may be involved in the carcinogenesis and development of GC and may provide useful clues for the prediction of the malignant behaviors of GC. |
Experiment for CHFR Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
123 |
123 |
MS-PCR; BGS |
China |
No Reports |
Up(Methylation) |
- |
- |
The methylation frequencies of CHFR in cancer tissues were significantly higher than those in corresponding normal gastric mucosae. The methylation status of CHFR was inversely related to the tumor size, tumor invasion depth and tumor differentiation in GC patients |
20300977 |
| tissue |
123 |
- |
RT-PCR; IHC |
China |
No Reports |
- |
- |
- |
The expression of the protein and mRNA decreased remarkably in the patients with aberrant promoter methylation of CHFR genes. |
20300977 |
| tissue |
123 |
- |
IHC |
China |
No Reports |
- |
- |
- |
The protein expression of CHFR were significantly correlated with tumor differentiation. |
20300977 |
Function for CHFR Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CHFR Gene
| Interaction Gene |
Method |
PMID |
|
