Search Result
Gene Summary for CIAPIN1 Gene
| Official Symbol |
CIAPIN1 |
Gene Type |
protein-coding |
| Full Name |
cytokine induced apoptosis inhibitor 1 |
Entrez |
57019
|
| Ensembl ID |
ENSG00000005194 |
HGNC |
28050
|
| Aliases |
Anamorsin, CIAE2, DRE2, PRO0915
|
Chromosome Location |
Chromosome 16, NC_000016.10 (57428187..57447385, complement)
|
| Expression |
Broad expression in testis (RPKM 38.4), placenta (RPKM 14.2) and 24 other tissues
|
| Summary |
CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004 [PubMed 14970183]).[supplied by OMIM, Mar 2008]
|
Paper for CIAPIN1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 19471113 |
Zhiming Hao |
2009 |
CIAPIN1 |
These results suggest that downregulated CIAPIN1 expression may contribute to gastric carcinogenesis by accelerating cell proliferation and promoting cell cycle progression. |
Experiment for CIAPIN1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
147 |
147 |
IHC |
China |
No Reports |
Down |
- |
- |
The expression of CIAPIN1 in gastric antral mucosa was progressively reduced along the sequence of normal/inflammatory gastric mucosa-atrophy-intestinal metaplasia-dysplasia-adenocarcinoma. The downregulation of CIAPIN1 in cancerous tissues was further confirmed by western blotting. No relationship between the expression level of CIAPIN1 and the clinicopathological parameters such as age, gender, differentiation, TNM stage and the existence of metastasis was found in gastric cancer patients. |
19471113 |
| cell line |
- |
- |
Cell proliferation assay; Flow cytometry |
- |
No Reports |
- |
- |
Ectopic expression of CIAPIN1 by cDNA transfection resulted in suppression of cell proliferation and inhibition of cell cycle progression while knockdown of CIAPIN1 with siRNA accelerated cell proliferation and promoted cell cycle progression in SGC7901 and MKN28 gastric cancer cells. |
Ectopic expression of CIAPIN1 by cDNA transfection resulted in suppression of cell proliferation and inhibition of cell cycle progression while knockdown of CIAPIN1 with siRNA accelerated cell proliferation and promoted cell cycle progression in SGC7901 and MKN28 gastric cancer cells. |
19471113 |
Function for CIAPIN1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CIAPIN1 Gene
| Interaction Gene |
Method |
PMID |
|
