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Gene Summary for CKS2 Gene
| Official Symbol |
CKS2 |
Gene Type |
protein-coding |
| Full Name |
CDC28 protein kinase regulatory subunit 2 |
Entrez |
1164
|
| Ensembl ID |
ENSG00000123975 |
HGNC |
2000
|
| Aliases |
CKSHS2
|
Chromosome Location |
Chromosome 9, NC_000009.12 (89311195..89316703)
|
| Expression |
Broad expression in testis (RPKM 88.8), bone marrow (RPKM 46.4) and 21 other tissues
|
| Summary |
CKS2 protein binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. The CKS2 mRNA is found to be expressed in different patterns through the cell cycle in HeLa cells, which reflects specialized role for the encoded protein. [provided by RefSeq, Jul 2008]
|
Paper for CKS2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 21617860 |
Fumiaki Tanaka |
2011 |
CKS2 |
CKS2 is a possible candidate gene for diagnosis, as well as targeted molecular diagnosis and therapy in gastric cancer. |
Experiment for CKS2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
109 |
109 |
qRT-PCR |
Japan |
No Reports |
Up |
- |
- |
The expression of CKS2 in gastric cancer is elevated relative to levels in normal tissue, and that CKS2 mRNA overexpression is associated with tumor differentiation, lymph node metastasis, distant metastasis, peritoneal dissemination and poor prognosis. In particular, CKS2 mRNA overexpression is associated with prognosis, as shown by multivariate analyses. |
21617860 |
| tissue |
109 |
109 |
IHC |
Japan |
No Reports |
Up |
- |
- |
Staining of CKS2 was markedly stronger in the human gastric cancer tissues than in the corresponding normal tissues. The expression of CKS2 was localized to the cell nucleus. |
21617860 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
The inhibition of cellular proliferation by CKS2-siRNA was observed in a gastric cancer cell line. |
The inhibition of cellular proliferation by CKS2-siRNA was observed in a gastric cancer cell line. |
21617860 |
Function for CKS2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
- |
- |
Interaction for CKS2 Gene
| Interaction Gene |
Method |
PMID |
|
