MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for CLCN3 Gene

Official Symbol CLCN3 Gene Type protein-coding
Full Name chloride voltage-gated channel 3 Entrez 1182
Ensembl ID ENSG00000109572 HGNC 2021
Aliases CLC3, ClC-3 Chromosome Location Chromosome 4, NC_000004.12 (169620578..169723673)
Expression Ubiquitous expression in brain (RPKM 27.7), colon (RPKM 19.9) and 25 other tissues
Summary This gene encodes a member of the voltage-gated chloride channel (ClC) family. The encoded protein is present in all cell types and localized in plasma membranes and in intracellular vesicles. It is a multi-pass membrane protein which contains a ClC domain and two additional C-terminal CBS (cystathionine beta-synthase) domains. The ClC domain catalyzes the selective flow of Cl- ions across cell membranes, and the CBS domain may have a regulatory function. This protein plays a role in both acidification and transmitter loading of GABAergic synaptic vesicles, and in smooth muscle cell activation and neointima formation. This protein is required for lysophosphatidic acid (LPA)-activated Cl- current activity and fibroblast-to-myofibroblast differentiation. The protein activity is regulated by Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in glioma cells. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Paper for CLCN3 Gene

PMID Author Year ID in Paper
 Conclusion
30217218 Zhuoyu Gu 2018 CLC-3 Overexpression of CLC-3 is regulated by XRCC5 and is a poor prognostic biomarker for gastric cancer. Double targeting CLC-3 and XRCC5 may provide the promising therapeutic potential for GC treatment.

Experiment for CLCN3 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 90 90 IHC China No Reports Up - - CLC-3 was overexpressed in human GC tissues and that overexpression of CLC-3 was a poor prognostic biomarker for GC patients (P = 0.012). Higher expression of CLC-3 was correlated with deeper tumor invasion (P = 0.006) and increased lymph node metastasis (P = 0.016) 30217218
cell line - - Cell proliferation assay; Cell invasion and migration assays; - No Reports - - Knockdown of CLC-3 inhibited cell proliferation and migration in vitro. Knockdown of CLC-3 inhibited cell proliferation and migration in vitro. 30217218
cell line - - Luciferase reporter assay;ChIP assay - No Reports - - - XRCC5 was identified as a CLC-3 promoter-binding protein, and both CLC-3 and XRCC5 were prognostic factors of overall survival in GC patients. 30217218
mice - - Xenograft mice models - No Reports - - - The expression and function of CLC-3 were regulated by XRCC5 in vivo 30217218

Function for CLCN3 Gene

Functional Type AUC Overall Survival Disease-free Survival
target/prognosis - 0.012 -

Interaction for CLCN3 Gene

Interaction Gene Method PMID
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