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Gene Summary for CLDN18 Gene
| Official Symbol |
CLDN18 |
Gene Type |
protein-coding |
| Full Name |
claudin 18 |
Entrez |
51208
|
| Ensembl ID |
ENSG00000066405 |
HGNC |
2039
|
| Aliases |
SFTA5, SFTPJ
|
Chromosome Location |
Chromosome 3, NC_000003.12 (137998816..138033649)
|
| Expression |
Biased expression in stomach (RPKM 335.4) and lung (RPKM 153.8)
|
| Summary |
This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jun 2010]
|
Paper for CLDN18 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24647998 |
Shi-jie Zhang |
2014 |
claudin-18 |
Downregulation of miR-1303 can inhibit proliferation, migration and invasion of GC cells by targeting CLDN18. |
Experiment for CLDN18 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
45 |
45 |
Western blot |
China |
No Reports |
Down |
Down |
- |
Claudin-18 was downregulated in tumor tissues with larger tumor size, intestinal histologic type, deeper local invasion and more advanced TNM stage. |
24647998 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-1303 could bind to the putative binding sites in CLDN18 mRNA 3'-UTR and visibly lower the expression of claudin-18. The introduction of claudin-18 without 3'-UTR restored the miR-1303 promoting migration function. |
24647998 |
Function for CLDN18 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CLDN18 Gene
| Interaction Gene |
Method |
PMID |
|
miR-1303 |
Luciferase reporter assay |
24647998
|
|
