Search Result
Gene Summary for CLEC4M Gene
| Official Symbol |
CLEC4M |
Gene Type |
protein-coding |
| Full Name |
C-type lectin domain family 4 member M |
Entrez |
10332
|
| Ensembl ID |
ENSG00000104938 |
HGNC |
13523
|
| Aliases |
CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN
|
Chromosome Location |
Chromosome 19, NC_000019.10 (7763243..7769605)
|
| Expression |
Biased expression in liver (RPKM 15.4), lymph node (RPKM 9.8) and 3 other tissues
|
| Summary |
This gene encodes a C-type lectin that functions in cell adhesion and pathogen recognition. This receptor recognizes a wide range of evolutionarily divergent pathogens with a large impact on public health, including tuberculosis mycobacteria, and viruses including Ebola, hepatitis C, HIV-1, influenza A, West Nile virus and the SARS-CoV acute respiratory syndrome coronavirus. The protein is organized into four distinct domains: a C-terminal carbohydrate recognition domain, a flexible tandem-repeat neck domain of variable length, a transmembrane region and an N-terminal cytoplasmic domain involved in internalization. This gene is closely related in terms of both sequence and function to a neighboring gene, CD209 (Gene ID: 30835), also known as DC-SIGN. The two genes differ in viral recognition and expression patterns, with this gene showing high expression in endothelial cells of the liver, lymph node and placenta. Polymorphisms in the tandem repeat neck domain are associated with resistance to SARS infection. [provided by RefSeq, May 2020]
|
Paper for CLEC4M Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28403883 |
Yu Zhang |
2017 |
DC-SIGNR |
DC-SIGNR promoted gastric cancer liver metastasis mediated with HNRNPKP2 which expression was regulated by STAT5A. And HNRNPKP2 decreased the expression of downstream target gene CXCR4. These findings indicated potential therapeutic candidates for gastric cancer liver metastasis. |
Experiment for CLEC4M Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| serum |
207 |
197 |
ELISA assay |
China |
No Reports |
Up |
Up |
- |
DC-SIGNR serum level was significantly increased in gastric cancer patients compared with healthy group. DC-SIGNR level was associated with an advanced pathological stage in gastric cancer patients. |
28403883 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay |
- |
No Reports |
- |
- |
DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and DC-SIGNR overexpression promoted cell proliferation, migration and invasion. |
DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and DC-SIGNR overexpression promoted cell proliferation, migration and invasion. |
28403883 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
DC-SIGNR knockdown suppressed the liver metastasis in vivo. |
28403883 |
Function for CLEC4M Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CLEC4M Gene
| Interaction Gene |
Method |
PMID |
|
