Search Result
Gene Summary for CMTM3 Gene
| Official Symbol |
CMTM3 |
Gene Type |
protein-coding |
| Full Name |
CKLF like MARVEL transmembrane domain containing 3 |
Entrez |
123920
|
| Ensembl ID |
ENSG00000140931 |
HGNC |
19174
|
| Aliases |
BNAS2, CKLFSF3
|
Chromosome Location |
Chromosome 16, NC_000016.10 (66603996..66613892)
|
| Expression |
Broad expression in testis (RPKM 24.7), placenta (RPKM 16.7) and 24 other tissues
|
| Summary |
This gene belongs to the chemokine-like factor gene superfamily, a novel family that is similar to the chemokine and the transmembrane 4 superfamilies of signaling molecules. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. Alternatively spliced transcript variants containing different 5' UTRs, but encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
|
Paper for CMTM3 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 24131472 |
Yu Su |
2014 |
CMTM3 |
CMTM3 regulates migration and invasion of gastric cancer cells. Moreover, CMTM3 is a candidate marker for prognosis of gastric cancer in the clinic. |
Experiment for CMTM3 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
6 |
6 |
qRT-PCR; Western blot |
China |
No Reports |
Down |
- |
- |
CMTM3 expression was dramatically downregulated in primary gastric cancer tissues. |
24131472 |
| tissue |
350 |
222 |
IHC |
China |
No Reports |
Down |
- |
- |
The expression of CMTM3 was remarkably weaker in gastric cancer tissues than in normal mucosae (P = 0.008), and was significantly correlated with gender (P = 0.033), tumor depth (P = 0.049), stage (P = 0.021), and histological grade (P = 0.022). CMTM3 expression was associated with prognosis in gastric cancer patients (P = 0.041), and was a significant independent prognostic indicator. |
24131472 |
| cell line |
- |
- |
Cell invasion and migration assay; |
- |
No Reports |
- |
- |
Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells |
Restoration of CMTM3 significantly affected migration and invasion of AGS and SGC-7901 cells |
24131472 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
In vivo experiments showed that peritoneal disseminated metastases were significantly suppressed by CMTM3. |
24131472 |
Function for CMTM3 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.041 |
- |
Interaction for CMTM3 Gene
| Interaction Gene |
Method |
PMID |
|
