MKGC: a curated molecular knowledgebase for gastric cancer


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Gene Summary for COL10A1 Gene

Official Symbol COL10A1 Gene Type protein-coding
Full Name collagen type X alpha 1 chain Entrez 1300
Ensembl ID ENSG00000123500 HGNC 2185
Aliases Chromosome Location Chromosome 6, NC_000006.12 (116118909..116219937, complement)
Expression Low expression observed in reference dataset
Summary This gene encodes the alpha chain of type X collagen, a short chain collagen expressed by hypertrophic chondrocytes during endochondral ossification. Unlike type VIII collagen, the other short chain collagen, type X collagen is a homotrimer. Mutations in this gene are associated with Schmid type metaphyseal chondrodysplasia (SMCD) and Japanese type spondylometaphyseal dysplasia (SMD). [provided by RefSeq, Jul 2008]

Paper for COL10A1 Gene

PMID Author Year ID in Paper
 Conclusion
30154451 Tingting Li 2018 COL10A1 COL10A1 might play a crucial role in GC progression and serve as a potential biomarker and therapeutic target in GC patients.

Experiment for COL10A1 Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 30 30 qRT-PCR; Western blot China No Reports Up - - COL10A1 was up-regulated in GC. We observed a positive correlation between the expression patterns of SOX9 and COL10A1 in GC cells and tissues. 30154451
tissue 103 - qRT-PCR China No Reports - - - The mRNA expression level of COL10A1 was significantly associated with tumor size, lymphatic emboli, lymph node metastasis, serosal invasion, AJCC stage, and recur_x005frence risk. 30154451
tissue 99 99 IHC China No Reports Up - - The protein expression level of COL10A1 was significantly upregulated in GC tissues and showed high concordance. The protein expression levels of COL10A1 and SOX9 were significantly correlated with tumor size, tumor differentiation, lymph node metastasis, and serosal invasion. The protein expression level of COL10A1 was associated with AJCC stage. COL10A1 was associated with a poor prognosis in GC patients. 30154451
cell line - - Cell invasion and migration assay - No Reports - - COL10A1 regulated the migration and invasion of GC cells. COL10A1 regulated the migration and invasion of GC cells. 30154451
mice - - Xenograft mice models - No Reports - - - Knockdown COL10A1 inhibited lung and abdominal cavity metastasis in a nude mouse model. 30154451
cell line - - Luciferase reporter assay; ChIP assay - No Reports - - - SOX9 directly binds to the COL10A1 promoter and activates its transcription. 30154451

Function for COL10A1 Gene

Functional Type AUC Overall Survival Disease-free Survival
prognosis - 0.003/0.000 -

Interaction for COL10A1 Gene

Interaction Gene Method PMID
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