Search Result
Gene Summary for COP1 Gene
| Official Symbol |
COP1 |
Gene Type |
protein-coding |
| Full Name |
COP1 E3 ubiquitin ligase |
Entrez |
64326
|
| Ensembl ID |
ENSG00000143207 |
HGNC |
17440
|
| Aliases |
CFAP78, FAP78, RFWD2, RNF200
|
Chromosome Location |
Chromosome 1, NC_000001.11 (175944831..176209087, complement)
|
| Expression |
Ubiquitous expression in testis (RPKM 5.8), colon (RPKM 4.2) and 25 other tissues
|
| Summary |
-
|
Paper for COP1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 23091414 |
Yuan-fang Li |
2012 |
COP1 |
COP1 could play an important role in gastric cancer and might serve as a valuable prognostic marker and potential target for gene therapy in the treatment of gastric cancer. |
Experiment for COP1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
40 |
40 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
The COP1 expression level was significantly higher in the 25 (62.5%) tumor-bearing tissues, com_x005fpared with the adjacent non-tumor tissues |
23091414 |
| tissue |
22 |
22 |
Western blot |
China |
No Reports |
Up |
- |
- |
High COP1 protein expression in most tumor-bearing tissues compared with the matched adjacent non-tumor tissues. The correlated protein expression analysis revealed a negative correlation between COP1 and p53 in gastric cancer samples. |
23091414 |
| tissue |
401 |
- |
IHC |
China |
No Reports |
- |
- |
- |
High COP1 expression was significantly correlated with T stage (P=0.030), M stage (P=0.048) and TNM stage (P=0.022). High expression of COP1 was significantly correlated with poor survival in gastric cancer patients (P<0.001). Cox regression analyses showed that COP1 expression was an independent predictor of overall survival. |
23091414 |
Function for COP1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.001 |
- |
Interaction for COP1 Gene
| Interaction Gene |
Method |
PMID |
|
