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Gene Summary for COPS7A Gene
| Official Symbol |
COPS7A |
Gene Type |
protein-coding |
| Full Name |
COP9 signalosome subunit 7A |
Entrez |
50813
|
| Ensembl ID |
ENSG00000111652 |
HGNC |
16758
|
| Aliases |
CSN7, CSN7A, SGN7a
|
Chromosome Location |
Chromosome 12, NC_000012.12 (6724046..6731868)
|
| Expression |
Ubiquitous expression in brain (RPKM 27.2), thyroid (RPKM 23.7) and 25 other tissues
|
| Summary |
This gene encodes a component of the COP9 signalosome, an evolutionarily conserved multi-subunit protease that regulates the activity of the ubiquitin conjugation pathway. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Mar 2014]
|
Paper for COPS7A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31409899 |
Jie Zheng |
2019 |
COPS7A |
For the first time, we revealed that KRT19P3 could suppress tumor growth and metastasis through COPS7A-mediated NF-B pathway, which may serve as potential targets for treatment of GC in the future. |
Experiment for COPS7A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
84 |
29 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
A significant decreased expression of COPS7A at mRNA levels in GC tissues compared with the non_x005ftumorous gastric tissues |
31409899 |
| tissue |
84 |
29 |
IHC |
China |
No Reports |
Down |
- |
- |
A significant decreased expression of COPS7A at protein levels in GC tissues compared with the non_x005ftumorous gastric tissues. Lower COPS7A expression was found to be associated with larger tumor size and positive lymph node metastasis. |
31409899 |
| cell line |
- |
- |
RNA pull-down assay; RIP; Western blot |
- |
No Reports |
- |
- |
- |
KRT19P3 could bind COPS7A directly and might regulate COPS7A activity in GC |
31409899 |
Function for COPS7A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for COPS7A Gene
| Interaction Gene |
Method |
PMID |
|
