Search Result
Gene Summary for CPXM2 Gene
| Official Symbol |
CPXM2 |
Gene Type |
protein-coding |
| Full Name |
carboxypeptidase X, M14 family member 2 |
Entrez |
119587
|
| Ensembl ID |
ENSG00000121898 |
HGNC |
26977
|
| Aliases |
CPX2, UNQ676
|
Chromosome Location |
Chromosome 10, NC_000010.11 (123745636..123944094, complement)
|
| Expression |
Broad expression in urinary bladder (RPKM 10.5), fat (RPKM 8.3) and 19 other tissues
|
| Summary |
-
|
Paper for CPXM2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31364750 |
Gengming Niu |
2019 |
CPXM2 |
Taken together, these results imply an active role for CPXM2 in promoting tumor aggressiveness via epithelial to mesenchymal transition (EMT) modulation in GCs. |
Experiment for CPXM2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
15 |
15 |
qRT-PCR; Western blot |
China |
No Reports |
Up |
- |
- |
CPXM2 mRNA and protein were elevated in the GC cases compared with the non-tumors. |
31364750 |
| tissue |
90 |
90 |
IHC |
China |
No Reports |
Up |
- |
- |
CPXM2 was expressed mainly in the cytoplasm and on the cytosolic side of the membrane, while its expression was stronger in GCs than in non tumors. High CPXM2 expression was significantly associated with larger tumor size and later pTNM stages.High CPXM2 expression had shorter overall survival (OS) times than did those with low expression. |
31364750 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; Cell colony formation assay |
- |
No Reports |
- |
- |
- |
CPXM2 promotes the proliferation and migration of cultured GC cells.CPXM2 may promote GC progression by modulating EMT |
31364750 |
Function for CPXM2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.007 |
- |
Interaction for CPXM2 Gene
| Interaction Gene |
Method |
PMID |
|
