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Gene Summary for CRK Gene
| Official Symbol |
CRK |
Gene Type |
protein-coding |
| Full Name |
CRK proto-oncogene, adaptor protein |
Entrez |
1398
|
| Ensembl ID |
ENSG00000167193 |
HGNC |
2362
|
| Aliases |
CRKII, p38
|
Chromosome Location |
Chromosome 17, NC_000017.11 (1420693..1456232, complement)
|
| Expression |
Ubiquitous expression in fat (RPKM 27.5), thyroid (RPKM 27.2) and 25 other tissues
|
| Summary |
This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]
|
Paper for CRK Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25027343 |
X Li |
2014 |
Crk |
MiR-126 expression was frequently and markedly downregulated (p < 0.05) in human gastric cancer tissues |
Experiment for CRK Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion assay |
- |
No Reports |
- |
- |
Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. |
Overexpression of miR-126 inhibited GC cells invasion but did not affect its proliferation in vitro. |
25027343 |
Function for CRK Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CRK Gene
| Interaction Gene |
Method |
PMID |
|
