Search Result
Gene Summary for CRMP1 Gene
| Official Symbol |
CRMP1 |
Gene Type |
protein-coding |
| Full Name |
collapsin response mediator protein 1 |
Entrez |
1400
|
| Ensembl ID |
ENSG00000072832 |
HGNC |
2365
|
| Aliases |
CRMP-1, DPYSL1, DRP-1, DRP1, ULIP-3
|
Chromosome Location |
Chromosome 4, NC_000004.12 (5820764..5893086, complement)
|
| Expression |
Biased expression in brain (RPKM 34.7), endometrium (RPKM 8.3) and 8 other tissues
|
| Summary |
This gene encodes a member of a family of cytosolic phosphoproteins expressed exclusively in the nervous system. The encoded protein is thought to be a part of the semaphorin signal transduction pathway implicated in semaphorin-induced growth cone collapse during neural development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
|
Paper for CRMP1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27864146 |
Lian Ren |
2017 |
CRMP1 |
miR-187 promotes tumor progression by regulating CRMP1 expression in GC and may thus be a potential prognostic marker and a therapeutic target in GC. |
Experiment for CRMP1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; |
- |
No Reports |
- |
- |
miR-187 significantly increased migration, invasion, and proliferation, but inhibited apoptosis in GC cells |
downregulation of CRMP1 increased cell proliferation and migration, and inhibited apoptosis in GC cells. Additionally, the inhibitory effect of the miR-187 inhibitor on cell migration was reversed by the downregulation of CRMP1. |
27864146 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CRMP1 was a direct downstream target of miR-187 in GC.The effects of miR-187 inhibitor on cell migration and cell apoptosis were reversed by CRMP1 downregulation |
27864146 |
Function for CRMP1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for CRMP1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-187 |
Luciferase reporter assay |
27864146
|
|
