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Gene Summary for CRNDE Gene

Official Symbol CRNDE Gene Type lncRNA
Full Name colorectal neoplasia differentially expressed Entrez 643911
Ensembl ID - HGNC 37078
Aliases CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 Chromosome Location Chromosome 16, NC_000016.10 (54918863..54928886, complement)
Expression Biased expression in testis (RPKM 14.7), lung (RPKM 2.1) and 8 other tissues
Summary This gene is transcribed into multiple transcript variants, some of which may function as non-coding RNAs. One of the transcript variants encodes a putative short protein that is localized to the nucleus (PMID:25978564). Expression of this locus is increased in proliferating tissues, including certain tumors such as colorectal adenomas and adenocarcinomas. Transcription from this gene is negatively regulated by insulin and insulin-like growth factors, and may regulate the expression of genes involved in metabolism. [provided by RefSeq, May 2015]

Paper for CRNDE Gene

PMID Author Year ID in Paper
 Conclusion
29243780 D-X Du 2017 CRNDE CRNDE plays an important role in promoting GC progression and may represent a novel prognostic biomarker in GC.
28490034 Cheng En Hu 2017 CRNDE CRNDE acted as a growth-promoting lncRNA in GC and maybe a potential target of GC treatment.

Experiment for CRNDE Gene

Sample Type Sample Number GC Sample Number nonGC Method Region Hpylori Normal vs. GC Early-stage vs. Advanced stage Biological Functions in GC Cells Result PMID
tissue 118 118 qRT-PCR China No Reports Up - - Expression of CRNDE was higher in GC tissues and cells compared with the normal gastric tissue and normal gastric cell lines. High expression of CRNDE was correlated with invasion depth, TNM stage and lymph node metastasis. Furthermore, high CRNDE expression was associated with shorter overall survival of GC patients. Multivariate analysis confirmed that high CRNDE expression was a significant independent predictor of poor survival in GC. 29243780
cell line - - Cell proliferation assay; Cell invasion and migration assays - No Reports - - Knockdown of CRNDE inhibited cell proliferation, migration and invasion of GC. Knockdown of CRNDE inhibited cell proliferation, migration and invasion of GC. 29243780
cell line - - Western blot; cell transfection - No Reports - - - CRNDE exerted its oncogenic role by affecting PI3K/AKT signaling pathways. 29243780
tissue 20 20 qRT-PCR China No Reports Up - - CRNDE was highly expressed in GC cell lines and tissues; 28490034
cell line - - Cell proliferation assay - No Reports - - Overexpression of CRNDE increased GC cell viability and promoted colony formation. Knockdown of CRNDE did not result in loss of expression-related effects on cell proliferation and colony formation. Overexpression of CRNDE increased GC cell viability and promoted colony formation. Knockdown of CRNDE did not result in loss of expression-related effects on cell proliferation and colony formation. 28490034
cell line - - Luciferase reporter assay - No Reports - - - miR-145 target gene E2F3 was strongly expressed following CRNDE competitive molecular sponging of miR-145. 28490034

Function for CRNDE Gene

Functional Type AUC Overall Survival Disease-free Survival
prognosis - 0.0066 -
target - - -

Interaction for CRNDE Gene

Interaction Gene Method PMID
MIR145 Luciferase reporter assay 28490034
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