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Gene Summary for CTBP1 Gene
| Official Symbol |
CTBP1 |
Gene Type |
protein-coding |
| Full Name |
C-terminal binding protein 1 |
Entrez |
1487
|
| Ensembl ID |
ENSG00000159692 |
HGNC |
2494
|
| Aliases |
BARS, HADDTS
|
Chromosome Location |
Chromosome 4, NC_000004.12 (1211444..1250355, complement)
|
| Expression |
Ubiquitous expression in spleen (RPKM 9.3), prostate (RPKM 7.1) and 25 other tissues
|
| Summary |
This gene encodes a protein that binds to the C-terminus of adenovirus E1A proteins. This phosphoprotein is a transcriptional repressor and may play a role during cellular proliferation. This protein and the product of a second closely related gene, CTBP2, can dimerize. Both proteins can also interact with a polycomb group protein complex which participates in regulation of gene expression during development. Alternative splicing of transcripts from this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
|
Paper for CTBP1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 27983935 |
Yingchao Li |
2018 |
CtBP1 |
through targeting CtBP1-mediated suppression of the EMT process, miR-644a might suppress the tumor metastasis of GC cells. |
Experiment for CTBP1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays |
- |
No Reports |
- |
- |
|
Suppression of CtBP1 Inhibits Proliferation, Invasion, and EMT Progression in GC Cells |
27983935 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
CtBP1 is a putative target gene of miR-644a in GC cells |
27983935 |
Function for CTBP1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CTBP1 Gene
| Interaction Gene |
Method |
PMID |
|
miR-644a |
Luciferase reporter assay |
27983935
|
|
