Gene Summary for CTHRC1 Gene
| Official Symbol |
CTHRC1 |
Gene Type |
protein-coding |
| Full Name |
collagen triple helix repeat containing 1 |
Entrez |
115908
|
| Ensembl ID |
ENSG00000164932 |
HGNC |
18831
|
| Aliases |
|
Chromosome Location |
Chromosome 8, NC_000008.11 (103371538..103382989)
|
| Expression |
Biased expression in gall bladder (RPKM 34.5), urinary bladder (RPKM 33.4) and 12 other tissues
|
| Summary |
This locus encodes a protein that may play a role in the cellular response to arterial injury through involvement in vascular remodeling. Mutations at this locus have been associated with Barrett esophagus and esophageal adenocarcinoma. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2012]
|
Paper for CTHRC1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25510669 |
Junbo Yu |
2015 |
Cthrc1 |
These results suggest that let-7b may directly target Cthrc1 and function as a tumor suppressor gene in GC. |
Experiment for CTHRC1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
47 |
47 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
Cthrc1 is upegulated in GC and inversely correlated with let-7b expression. |
25510669 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
Cthrc1 was a direct target of let-7b. |
25510669 |
Function for CTHRC1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for CTHRC1 Gene
| Interaction Gene |
Method |
PMID |
|
let-7b |
Luciferase reporter assay |
25510669
|
