Search Result
Gene Summary for DDX5 Gene
| Official Symbol |
DDX5 |
Gene Type |
protein-coding |
| Full Name |
DEAD-box helicase 5 |
Entrez |
1655
|
| Ensembl ID |
ENSG00000108654 |
HGNC |
2746
|
| Aliases |
G17P1, HLR1, HUMP68, p68
|
Chromosome Location |
Chromosome 17, NC_000017.11 (64498254..64506866, complement)
|
| Expression |
Ubiquitous expression in bone marrow (RPKM 190.1), lymph node (RPKM 152.4) and 25 other tissues
|
| Summary |
This gene encodes a member of the DEAD box family of RNA helicases that are involved in a variety of cellular processes as a result of its role as an adaptor molecule, promoting interactions with a large number of other factors. This protein is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. Members of this family contain nine conserved motifs, including the conserved Asp-Glu-Ala-Asp (DEAD) motif, important to ATP binding and hydrolysis as well as RNA binding and unwinding activities. Dysregulation of this gene may play a role in cancer development. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2017]
|
Paper for DDX5 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30029874 |
Nan Wu |
2018 |
DDX5 |
We confirmed the effect of miR-5590-3p directly targeting DDX5 on the development of gastric cancer through salvage experiments in vivo and in vitro. |
Experiment for DDX5 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
42 |
42 |
qRT-PCR |
China |
No Reports |
Up |
- |
- |
DDX5 expression in gastric cancer is significantly higher in corresponding non-cancerous gastric tissues, and the expression of miR-5590-3p and DDX5 was significantly negatively correlated in gastric cancer |
30029874 |
| cell line |
- |
- |
RIP and Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
miR-5590-3p as a direct target of DDX5 |
30029874 |
Function for DDX5 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for DDX5 Gene
| Interaction Gene |
Method |
PMID |
|
