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Gene Summary for DICER1 Gene
| Official Symbol |
DICER1 |
Gene Type |
protein-coding |
| Full Name |
dicer 1, ribonuclease III |
Entrez |
23405
|
| Ensembl ID |
ENSG00000100697 |
HGNC |
17098
|
| Aliases |
CR1; GLOW; MNG1; aviD; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
|
Chromosome Location |
Chromosome 14, NC_000014.9 (95086228..95158263, complement)
|
| Expression |
Biased expression in lymph node (RPKM 35.2), appendix (RPKM 32.5) and 6 other tissues
|
| Summary |
This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
|
Paper for DICER1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 23519840 |
Wei-ning Wang |
2013 |
DICER1 |
CCR7 protein plays a key role in the metastasis and progression of gastric cancer. The elevated CCR7 protein expression may be caused by the deficiency of let-7a miRNA expression due to the downregulation of DICER1gene expression. The mechanism for the silencing of DICER1 gene expression requires further studies. |
Experiment for DICER1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
80 |
40 |
IHC |
China |
No Reports |
Up |
- |
- |
Dicer 1 protein expression was found to be significantly reduced; Dicer 1 protein positively correlated with let-7a miRNA level, but negatively correlated with CCR7 protein level in gastric adenocarcinoma; Negative Dicer 1 protein expression significantly correlated with lymph node metastasis, depth of invasion, high clinical TNM stage, and larger tumor size. low expression of Dicer 1 protein is significantly associated with the metastasis and progression of gastric cancer. |
23519840 |
Function for DICER1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
Interaction for DICER1 Gene
| Interaction Gene |
Method |
PMID |
|
