Search Result
Gene Summary for DNMT3A Gene
| Official Symbol |
DNMT3A |
Gene Type |
protein-coding |
| Full Name |
DNA methyltransferase 3 alpha |
Entrez |
1788
|
| Ensembl ID |
ENSG00000119772 |
HGNC |
2978
|
| Aliases |
DNMT3A2, HESJAS, M.HsaIIIA, TBRS
|
Chromosome Location |
Chromosome 2, NC_000002.12 (25227874..25342590, complement)
|
| Expression |
Ubiquitous expression in placenta (RPKM 5.8), ovary (RPKM 3.9) and 25 other tissues
|
| Summary |
CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016]
|
Paper for DNMT3A Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26350239 |
He Cui |
2015 |
DNMT3A |
DNMT3A contributes to the dysregulation of the cell cycle by repressing p18INK4C in a DNA methylation-dependent manner, suggesting that DNMT3A-p18INK4C axis involved in GC. These findings provide new insights into gastric carcinogenesis and a potential therapeutic target for GC that may be further investigated in the future. |
Experiment for DNMT3A Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
35 |
35 |
Western blot |
China |
No Reports |
Up |
- |
- |
The average expression level of DNMT3A in the tumor tissues was signif_x005ficantly higher than that in the paired adjacent non-tumor tissues. DNMT3A overexpression was strongly correlated with tumor cell differentiation. |
26350239 |
| cell line |
- |
- |
Cell proliferation assay; Flow Cytometry |
- |
No Reports |
- |
- |
DNMT3A promotes tumor cell proliferation and cell growth by disrupting the G1/S checkpoint. |
DNMT3A promotes tumor cell proliferation and cell growth by disrupting the G1/S checkpoint. |
26350239 |
| mice |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
DNMT3A promotes tumor cell proliferation in vivo |
26350239 |
| cell line |
- |
- |
ChIP assay |
- |
No Reports |
- |
- |
- |
DNMT3A modulated p18INK4C by directly binding to and silencing the p18INK4C gene via promoter hypermethylation. |
26350239 |
Function for DNMT3A Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for DNMT3A Gene
| Interaction Gene |
Method |
PMID |
|
