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Gene Summary for EGFR Gene
| Official Symbol |
EGFR |
Gene Type |
protein-coding |
| Full Name |
epidermal growth factor receptor |
Entrez |
1956
|
| Ensembl ID |
ENSG00000146648 |
HGNC |
3236
|
| Aliases |
ERBB, ERBB1, HER1, NISBD2, PIG61, mENA
|
Chromosome Location |
Chromosome 7, NC_000007.14 (55019017..55211628)
|
| Expression |
Broad expression in placenta (RPKM 36.6), skin (RPKM 15.6) and 22 other tissues
|
| Summary |
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor, thus inducing receptor dimerization and tyrosine autophosphorylation leading to cell proliferation. Mutations in this gene are associated with lung cancer. EGFR is a component of the cytokine storm which contributes to a severe form of Coronavirus Disease 2019 (COVID-19) resulting from infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). [provided by RefSeq, Jul 2020]
|
Paper for EGFR Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30530570 |
Yan Jia |
2019 |
EGFR |
A tumor-suppressive role of miR-1296-5p through the translational repression of oncogenic CDK6 and EGFR in gastric cancer. |
Experiment for EGFR Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
40 |
40 |
IHC |
China |
No Reports |
- |
- |
- |
EGFR and CDK6 are up-regulated in GC and negatively correlated with miR-1296-5p |
30530570 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
EGFR and CDK6 are directly targets of miR-1296-5p |
30530570 |
Function for EGFR Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for EGFR Gene
| Interaction Gene |
Method |
PMID |
|
miR-1296-5p |
Luciferase reporter assay |
30530570
|
|
