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Gene Summary for ELAVL1 Gene
| Official Symbol |
ELAVL1 |
Gene Type |
protein-coding |
| Full Name |
ELAV like RNA binding protein 1 |
Entrez |
1994
|
| Ensembl ID |
ENSG00000066044 |
HGNC |
3312
|
| Aliases |
ELAV1, HUR, Hua, MelG
|
Chromosome Location |
Chromosome 19, NC_000019.10 (7958573..8005641, complement)
|
| Expression |
Ubiquitous expression in testis (RPKM 14.6), brain (RPKM 9.9) and 25 other tissues
|
| Summary |
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]
|
Paper for ELAVL1 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 26819420 |
Ning Zhou |
2016 |
HuR |
MiR-519 may inhibit the gastric cancer cell activity through suppression of HuR expression. |
Experiment for ELAVL1 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
Over-expression of HuR resulted in the increase in the cell activity of gastric cancer |
Over-expression of HuR resulted in the increase in the cell activity of gastric cancer (P<0.001). Suppression of HuR decreased the cell activity of gastric cancer (P=0.001). |
26819420 |
| cell line |
- |
- |
Western blot |
- |
No Reports |
- |
- |
- |
The protein level of HuR in the gastric cancer cells was higher than that in the control cells. |
26819420 |
Function for ELAVL1 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| mechanism |
- |
- |
- |
Interaction for ELAVL1 Gene
| Interaction Gene |
Method |
PMID |
|
