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Gene Summary for EPHA8 Gene
| Official Symbol |
EPHA8 |
Gene Type |
protein-coding |
| Full Name |
EPH receptor A8 |
Entrez |
2046
|
| Ensembl ID |
ENSG00000070886 |
HGNC |
3391
|
| Aliases |
EEK, EK3, HEK3
|
Chromosome Location |
Chromosome 1, NC_000001.11 (22563489..22603595)
|
| Expression |
Low expression observed in reference dataset
|
| Summary |
This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]
|
Paper for EPHA8 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 31026069 |
Yingjing Wang |
2019 |
EphA8 |
EphA8, which is highly expressed in GC tissues, stimulates proliferation, invasion, and migration of cancer cells, and is an independent risk factor for poor prognosis of GC. |
Experiment for EPHA8 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
206 |
92 |
IHC |
China |
No Reports |
Up |
- |
- |
Upregulated in GC tissues compared with nontumor tissues; EphA8 expression was also strongly associated with differentiation level, tumor-node-metastasis stage, and poor 5 years survival. A panel of GC cell lines showed reduced proliferation, invasion, and migration capacities after RNA-mediated knockdown of EphA8, concomitant with downregulation of the proliferation-related proteins (cyclin A, cyclin D1, and cyclin-dependent kinase 4) and the metastasis-related (matrix metalloproteinases MMP2, and MMP9). EphA8 knockdown also decreased expression of the protease ADAM10 (a disintegrin and metalloproteinase domain-containing protein 10) and ADAM10-related protein AKT, suggesting an interaction between EphA8 and ADAM10. |
31026069 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays |
- |
No Reports |
- |
- |
Knockdown of Epha8 reduces cell proliferation; EphA8 promotes GC cell migration and invasion |
Knockdown of Epha8 reduces cell proliferation; EphA8 promotes GC cell migration and invasion |
31026069 |
| cell line |
- |
- |
Western blot; Coimmuno precipitation experiments;Immunofluorescence microscopy |
- |
No Reports |
- |
- |
EphA8 interacts with ADAM10 to affect GC cell growth |
EphA8 interacts with ADAM10 to affect GC cell growth |
31026069 |
Function for EPHA8 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
< 0.001 |
- |
| prognosis |
- |
< 0.001 |
- |
Interaction for EPHA8 Gene
| Interaction Gene |
Method |
PMID |
|
