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Gene Summary for ERBB4 Gene
| Official Symbol |
ERBB4 |
Gene Type |
protein-coding |
| Full Name |
erb-b2 receptor tyrosine kinase 4 |
Entrez |
2066
|
| Ensembl ID |
ENSG00000178568 |
HGNC |
3432
|
| Aliases |
ALS19, HER4, p180erbB4
|
Chromosome Location |
Chromosome 2, NC_000002.12 (211375717..212538802, complement)
|
| Expression |
Biased expression in kidney (RPKM 3.0), brain (RPKM 2.7) and 8 other tissues
|
| Summary |
This gene is a member of the Tyr protein kinase family and the epidermal growth factor receptor subfamily. It encodes a single-pass type I membrane protein with multiple cysteine rich domains, a transmembrane domain, a tyrosine kinase domain, a phosphotidylinositol-3 kinase binding site and a PDZ domain binding motif. The protein binds to and is activated by neuregulins and other factors and induces a variety of cellular responses including mitogenesis and differentiation. Multiple proteolytic events allow for the release of a cytoplasmic fragment and an extracellular fragment. Mutations in this gene have been associated with cancer. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
|
Paper for ERBB4 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29620274 |
Ji Xu |
2018 |
ERBB4 |
ERBB4 regulates cell proliferation mainly through the PI3K signaling pathway. Finally, nude mice xenografted with gastric cancer cells with low expression of ERBB4 exhibited smaller tumors and longer survival than those engrafted with control gastric cancer cells. These data indicated that ERBB4 promoted cell proliferation and is thus a potential therapeutic target for the treatment of gastric cancer. |
Experiment for ERBB4 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
27 |
27 |
Western blot |
China |
No Reports |
Up |
- |
- |
ERBB4 was highly expressed in gastric cancer tissues when compared to the normal stomach samples. |
29620274 |
| cell line |
- |
- |
Cell proliferation assay |
- |
No Reports |
- |
- |
Silencing of ERBB4 expression suppresses tumor growth |
Silencing of ERBB4 expression suppresses GC cell proliferation. |
29620274 |
| mice |
- |
- |
Xenograft mouse models |
- |
No Reports |
- |
- |
- |
Silencing of ERBB4 expression suppresses tumor growth in vivo. |
29620274 |
| mice |
- |
- |
IHC |
- |
No Reports |
- |
- |
- |
inhibitor of ERBB4 (AST-1306) significantly downregulated the expression level of the prolif- eration-related proteins PI3K and Akt |
29620274 |
Function for ERBB4 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for ERBB4 Gene
| Interaction Gene |
Method |
PMID |
|
