Gastric Cancer Database

Official Symbol	ETS1	Gene Type	protein-coding
Full Name	ETS proto-oncogene 1, transcription factor	Entrez	2113
Ensembl ID	ENSG00000134954	HGNC	3488
Aliases	ETS-1, EWSR2, c-ets-1, p54	Chromosome Location	Chromosome 11, NC_000011.10 (128458765..128587593, complement)
Expression	Broad expression in lymph node (RPKM 31.2), spleen (RPKM 21.4) and 22 other tissues
Summary	This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]

PMID	Author	Year	ID in Paper	Conclusion
29848678	Nan-Hua Chou	2018	ETS1	miR-193a-3p suppressed gastric growth and motility, at least partly, by directly targeting CCND1 and ETS1 expression.
23383271	Liduan Zheng	2013	Ets1	anti-miR-9 inhibitor promoted the proliferation, migration and invasion of gastric cancer cells, while knocking down of cyclin D1 or Ets1 partially phenocopied the effects of miR-9 over-expression.

Sample Type	Sample Number GC	Sample Number nonGC	Method	Region	Hpylori	Normal vs. GC	Early-stage vs. Advanced stage	Biological Functions in GC Cells	Result	PMID
cell line	-	-	Cell proliferation assay; Cell colony formation assay;	-	No Reports	-	-	Ectopic expressions of miR-193a-5p and miR-193a-3p revealed that they both inhibited gastric cancer cell growth, but only miR-193a-3p significantly suppressed cell invasion ability.	ETS1 or CCND1 knockdown significantly suppressed gastric cancer cell growth, similar to miR-193a-3p overexpression.	29848678
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	ETS1 and CCND1 are direct targets of miR-193a-3p	29848678
tissue	86	86	qRT-PCR	China	No Reports	Up	-	-	Ets1 was found to be up-regulated and inversely correlated with the expression of miR-9 in gastric cancer tissues and cell lines.	23383271
cell line	-	-	Cell proliferation assay; Invasion and migration assays; Flow Cytometry; Cell colony formation assay	-	No Reports	-	-	Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro.	Knockdown of cyclin D1 and Ets1 phenocopied miR-9 over-expression-mediated inhibition on the proliferation, migration and invasion of gastric cancer cells in vitro.	23383271
cell line	-	-	Luciferase reporter assay	-	No Reports	-	-	-	miR-9 directly targeted the 3'-UTR of cyclin D1 and Ets1	23383271

Functional Type	AUC	Overall Survival	Disease-free Survival
mechanism	-	-	-