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Gene Summary for EZH2 Gene
| Official Symbol |
EZH2 |
Gene Type |
protein-coding |
| Full Name |
enhancer of zeste 2 polycomb repressive complex 2 subunit |
Entrez |
2146
|
| Ensembl ID |
ENSG00000106462 |
HGNC |
3527
|
| Aliases |
ENX-1, ENX1b, KMT6, KMT6A, WVS, WVS2, EZH2
|
Chromosome Location |
Chromosome 7, NC_000007.14 (148807374..148884344, complement)
|
| Expression |
Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.6) and 14 other tissues
|
| Summary |
This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
|
Paper for EZH2 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 30952377 |
Jiewei Xu |
2019 |
EZH2 |
EZH2 over-expression can be identified as a poor prognostic biomarker in gastric cancer. |
Experiment for EZH2 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
89 |
89 |
IHC |
China |
No Reports |
Up |
- |
- |
EZH2 levels were increased in gastric cancer tissues compared with adjacent normal tissues. Moreover, patients with high levels of EZH2 expression had a relatively poor prognosis. Furthermore, and vivo. Finally, we found that EZH2 influences gastric cancer cells proliferation partly through regulating p21 expression |
30952377 |
| cell line |
- |
- |
Cell proliferation assay; Cell invasion and migration assays; |
- |
No Reports |
- |
- |
knockdown of EZH2 expression by siRNA could impair cell proliferation and invasion both in vitro. |
knockdown of EZH2 expression by siRNA could impair cell proliferation and invasion both in vitro. |
30952377 |
| cell line |
- |
- |
Xenograft mice models |
- |
No Reports |
- |
- |
- |
Knockdown of EZH2 inhibits gastric cancer cells tumorigenesis in vivo. |
30952377 |
| cell line |
- |
- |
CHIP assay |
- |
No Reports |
- |
- |
- |
EZH2 could directly bind to P21 promoter region and mediate H3K27me3 modification. |
30952377 |
Function for EZH2 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| prognosis |
- |
0.001 |
- |
Interaction for EZH2 Gene
| Interaction Gene |
Method |
PMID |
|
