Search Result
Gene Summary for FADD Gene
| Official Symbol |
FADD |
Gene Type |
protein-coding |
| Full Name |
Fas associated via death domain |
Entrez |
8772
|
| Ensembl ID |
ENSG00000168040 |
HGNC |
3573
|
| Aliases |
GIG3, MORT1
|
Chromosome Location |
Chromosome 11, NC_000011.10 (70203296..70207390)
|
| Expression |
Ubiquitous expression in kidney (RPKM 9.3), colon (RPKM 8.7) and 25 other tissues
|
| Summary |
The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]
|
Paper for FADD Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28848149 |
Jin Yan |
2017 |
FADD |
A novel regulatory pathway H19/miR-675/ FADD/caspase 8/caspase 3 in gastric cancer which may be potential target for cancer therapy. |
Experiment for FADD Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
34 |
34 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
By further examining the underlying mechanism, we showed that H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. |
28848149 |
| cell line |
- |
- |
Luciferase reporter assay |
- |
No Reports |
- |
- |
- |
FADD is a potential target of miR-675; H19/miR-675 axis inhibited expression of FADD. FADD downregulation subsequently inhibited the caspase cleavage cascades including caspase 8 and caspase 3. |
28848149 |
| cell line |
- |
- |
Cell proliferation assay; Colony formation assay; Flow cytometry |
- |
No Reports |
- |
- |
FADD mediates the pro-proliferation and anti-apoptosis function of miR-675 |
FADD mediates the pro-proliferation and anti-apoptosis function of miR-675 |
28848149 |
Function for FADD Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for FADD Gene
| Interaction Gene |
Method |
PMID |
|
miR-675 |
Luciferase reporter assay |
28848149
|
|
