Search Result
Gene Summary for FZD7 Gene
| Official Symbol |
FZD7 |
Gene Type |
protein-coding |
| Full Name |
frizzled class receptor 7 |
Entrez |
8324
|
| Ensembl ID |
ENSG00000155760 |
HGNC |
4045
|
| Aliases |
FzE3
|
Chromosome Location |
Chromosome 2, NC_000002.12 (202033855..202038441)
|
| Expression |
-
|
| Summary |
Members of the 'frizzled' gene family encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The FZD7 protein contains an N-terminal signal sequence, 10 cysteine residues typical of the cysteine-rich extracellular domain of Fz family members, 7 putative transmembrane domains, and an intracellular C-terminal tail with a PDZ domain-binding motif. FZD7 gene expression may downregulate APC function and enhance betaβ-catenin-mediated signals in poorly differentiated human esophageal carcinomas. [provided by RefSeq, Jul 2008]
|
Paper for FZD7 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 29559846 |
Guanman Li |
2018 |
Frizzled7 |
Wnt canonical pathway may contribute to tumorigenesis and metastasis, indicating that FZD7 could be a potential therapeutic target for gastric cancer. |
Experiment for FZD7 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
251 |
60 |
IHC |
China |
Not Related |
Up |
- |
- |
FZD7 was overexpressed in clinical GC samples, and thus was correlated with tumor invasion, lymphatic and organ metastasis, late TNM stages and poor patient survival. Furthermore, RNA interference-mediated . Moreover, ablation of FZD7 down-regulated EMT and the expression levels of cancer stem cell markers, and these inhibitions were associated with attenuated canonical Wnt/β-catenin signaling |
29559846 |
| cell line |
- |
- |
Cell proliferation assay; Invasion and migration assays; Flow cytometry |
- |
No Reports |
- |
- |
Knockdown of FZD7 suppressed gastric cancer cell growth, migration and invasion |
Knockdown of FZD7 suppressed gastric cancer cell growth, migration and invasion |
29559846 |
Function for FZD7 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target/prognosis |
- |
< 0.001 |
< 0.001 |
Interaction for FZD7 Gene
| Interaction Gene |
Method |
PMID |
|
