Search Result
Gene Summary for GAS5 Gene
| Official Symbol |
GAS5 |
Gene Type |
lncRNA |
| Full Name |
growth arrest specific 5 |
Entrez |
60674
|
| Ensembl ID |
ENSG00000234741 |
HGNC |
16355
|
| Aliases |
NCRNA00030, SNHG2
|
Chromosome Location |
Chromosome 1, NC_000001.11 (173863899..173868882, complement)
|
| Expression |
Ubiquitous expression in ovary (RPKM 307.5), thyroid (RPKM 113.4) and 24 other tissues
|
| Summary |
This gene produces a spliced long non-coding RNA and is a member of the 5' terminal oligo-pyrimidine class of genes. It is a small nucleolar RNA host gene, containing multiple C/D box snoRNA genes in its introns. Part of the secondary RNA structure of the encoded transcript mimics glucocorticoid response element (GRE) which means it can bind to the DNA binding domain of the glucocorticoid receptor (nuclear receptor subfamily 3, group C, member 1). This action blocks the glucocorticoid receptor from being activated and thereby stops it from regulating the transcription of its target genes. This transcript is also thought to regulate the transcriptional activity of other receptors, such as androgen, progesterone and mineralocorticoid receptors, that can bind to its GRE mimic region. Multiple functions have been associated with this transcript, including cellular growth arrest and apoptosis. It has also been identified as a potential tumor suppressor, with its down-regulation associated with cancer in multiple different tissues. [provided by RefSeq, Mar 2015]
|
Paper for GAS5 Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 25959498 |
Yongchao Liu |
2015 |
lncRNA GAS5 |
These results delineate a novel mechanism of lncRNA GAS5 in suppressing stomach carcinogenesis, and the lncRNA GAS5/YBX1/p21 pathway we discovered may provide useful targets for developing lncRNA-based therapies for stomach cancer. |
Experiment for GAS5 Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
55 |
55 |
qRT-PCR |
China |
No Reports |
Down |
- |
- |
lncRNA GAS5 had lower expression in stomach cancer tissues than the normal counterparts. p21 expression correlates with lncRNA GAS5 expression in stomach cancer tissues. |
25959498 |
| cell line |
- |
- |
Flow cytometry |
- |
No Reports |
- |
- |
lncRNA GAS5 knock-down abolishes cell cycle arrest at the G1 phase |
lncRNA GAS5 knock-down abolishes cell cycle arrest at the G1 phase |
25959498 |
| cell line |
- |
- |
RNA pull-down assay |
- |
No Reports |
- |
- |
- |
lncRNA GAS5 interacts with the transcriptional activator YBX1. |
25959498 |
Function for GAS5 Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for GAS5 Gene
| Interaction Gene |
Method |
PMID |
|
