Search Result
Gene Summary for GNAQ Gene
| Official Symbol |
GNAQ |
Gene Type |
protein-coding |
| Full Name |
G protein subunit alpha q |
Entrez |
2776
|
| Ensembl ID |
ENSG00000156052 |
HGNC |
4390
|
| Aliases |
CMC1, G-ALPHA-q, GAQ, SWS
|
Chromosome Location |
Chromosome 9, NC_000009.12 (77716097..78031811, complement)
|
| Expression |
Ubiquitous expression in brain (RPKM 36.1), lung (RPKM 23.2) and 25 other tissues
|
| Summary |
This locus encodes a guanine nucleotide-binding protein. The encoded protein, an alpha subunit in the Gq class, couples a seven-transmembrane domain receptor to activation of phospolipase C-beta. Mutations at this locus have been associated with problems in platelet activation and aggregation. A related pseudogene exists on chromosome 2.[provided by RefSeq, Nov 2010]
|
Paper for GNAQ Gene
| PMID |
Author |
Year |
ID in Paper
|
Conclusion |
| 28350126 |
Yizhuo Wang |
2017 |
GNAQ |
GNAQ plays a critical role in regulating GC cell growth and survival via canonical oncogenic signaling pathways including MAPK and p53, and therefore serves as a promising new therapeutic target in GC. |
Experiment for GNAQ Gene
| Sample Type |
Sample Number GC |
Sample Number nonGC |
Method |
Region |
Hpylori |
Normal vs. GC |
Early-stage vs. Advanced stage |
Biological Functions in GC Cells |
Result |
PMID |
| tissue |
280 |
280 |
IHC |
China |
No Reports |
Up |
No |
- |
GNAQ was highly expressed in GC patient samples and GNAQ expression was related to patient age, GC differentiation status and adjuvant therapy, as determined by immunohistochemical assay. Mechanistic analysis revealed that knockdown of GNAQ significantly increased the expression of p53 and p21, and decreased cyclin A and p-CDK2 protein expression. Moreover, the phosphorylation of ERK and MEK was also decreased after knockdown of GNAQ as determined by western blotting assay |
28350126 |
| cell line |
- |
- |
Cell proliferation assay; Cell colony formation assay; Flow cytometry |
- |
No Reports |
- |
- |
Silencing of GNAQ markedly suppressed proliferation and colony formation in GC cells, and arrested the cell cycle at the S phase. |
Silencing of GNAQ markedly suppressed proliferation and colony formation in GC cells, and arrested the cell cycle at the S phase. |
28350126 |
| cell line |
- |
- |
Western blot; cell transfection |
- |
No Reports |
- |
- |
- |
GNAQ directly or indirectly inhibits p53 and several key regulators of cell cycle signaling. GNAQ expression was required for MEK/ERK phosphorylation in MGC80-3 cells. |
28350126 |
Function for GNAQ Gene
| Functional Type |
AUC |
Overall Survival |
Disease-free Survival |
| target |
- |
- |
- |
Interaction for GNAQ Gene
| Interaction Gene |
Method |
PMID |
|
